Non-Small Cell Lung Cancer from Genomics to Therapeutics: A Framework for Community Practice Integration to Arrive at Personalized Therapy Strategies
| Autor: | Swapnil Rajurkar, TingTing Tan, Isa Mambetsariev, Ravi Salgia, Benjamin I. Leach, Prakash Kulkarni, Rebecca Pharaon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty driver mutations lcsh:Medicine Genomics Disease Review team medicine medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Electronic health record Internal medicine Medicine Personalized therapy Lung cancer non-small cell lung cancer 030304 developmental biology 0303 health sciences testing rates receptor tyrosine kinases business.industry lcsh:R General Medicine medicine.disease 030220 oncology & carcinogenesis Community practice Non small cell business Carcinogenesis |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 1870, p 1870 (2020) Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Popis: | Non-small cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced with the identification of various key oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalizing therapy based on the molecular genomics of the tumor. This review presents approved treatments against actionable mutations in NSCLC as well as promising targets and therapies. We also discuss the current status of molecular testing practices in community oncology sites that would help to direct oncologists in lung cancer decision-making. We propose a collaborative framework between community practice and academic sites that can help improve the utilization of personalized strategies in the community, through incorporation of increased testing rates, virtual molecular tumor boards, vendor-based oncology clinical pathways, and an academic-type singular electronic health record system. |
| Databáze: | OpenAIRE |
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