SR 48692, a non-peptide neurotensin receptor antagonist, blocks the cardiovascular effects elicited by neurotensin in guinea pigs

Autor:	Pierre Guiraudou, D. Nisato, G. Le Fur, Gérard Barthélémy, Danielle Gully
Rok vydání:	1994
Předmět:	Male medicine.medical_specialty Guinea Pigs Blood Pressure In Vitro Techniques Biology Cardiovascular System complex mixtures General Biochemistry Genetics and Molecular Biology Contractility Guinea pig chemistry.chemical_compound In vivo Internal medicine medicine Animals Receptors Neurotensin Heart Atria Neurotensin receptor General Pharmacology Toxicology and Pharmaceutics Receptor Neurotensin Dose-Response Relationship Drug digestive oral and skin physiology Antagonist General Medicine Dose–response relationship Endocrinology chemistry Quinolines Pyrazoles hormones hormone substitutes and hormone antagonists Muscle Contraction
Zdroj:	Life Sciences. 54:PL95-PL100
ISSN:	0024-3205
DOI:	10.1016/0024-3205(94)00411-0
Popis:	In guinea pigs anaesthetized with sodium pentobarbital, SR 48692, a non peptide neurotensin receptor antagonist blunted the blood pressure increase induced by exogenous neurotensin in a dose dependent manner. Furthermore, in asolated spontaneously beating guinea pig atria, both the tachycardia and inotropic responses induced by neurotensin were potently antagonized. SR 48692 did not show any intrinsic effect in vivo or in vitro .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b5352172f066ea334ac539ba027b4e https://doi.org/10.1016/0024-3205(94)00411-0 Zobrazit plný text záznamu