| Autor: |
M.E. Sanchez, Leroy C. McLaren, Arthur D. Bankhurst, D.V.J. Maki |
| Rok vydání: |
1980 |
| Předmět: |
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| Zdroj: |
Cellular Immunology. 52:350-358 |
| ISSN: |
0008-8749 |
| DOI: |
10.1016/0008-8749(80)90356-1 |
| Popis: |
Corticosteroids have been shown to have an inhibitory effect on many aspects of the human inflammatory and immunologic response. It is largely unknown by what mechanism corticosteroids alter the biologic function of lymphoid cells. One possible mechansim by which steroids could alter lymphocyte function is by modulation of surface receptors. The present study was designed to examine this possibility by the study of the effect of hydrocortisone (HC) and other steroids on the lymphocyte surface binding site for measles virus antigens. These receptors were detected by an assay involving the rosetting of lymphocytes to measles-infected Hela cells (Hela-K11). We showed that HC and several other steroids inhibit the adherence of monocyte-depleted peripheral blood lymphocytes to Hela-K11 cells (HC inhibition, 34 ± 12.1%, mean ± 1 SD). Inhibition could only be observed after the removal of glass-adherent cells. Modulation of lymphocyte functional surface determinants may be important in explaining some of the pharmacologic effects of corticosteroids on the immune system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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