Effect of Cholestyramine on Fecal Bile Salt Excretion in Rats Fed Diets Containing Medium-Chain Triglycerides or Corn Oil
| Autor: | D. L. Schneider, L. M. Hagerman |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Cholestyramine Resin Salt (chemistry) Binding Competitive digestive system General Biochemistry Genetics and Molecular Biology Bile Acids and Salts Excretion Feces Internal medicine medicine Animals Food science chemistry.chemical_classification Cholestyramine Fatty acid Dietary Fats Rats Binding ability Endocrinology Intestinal Absorption chemistry Composition (visual arts) Oils Corn oil medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 143:93-96 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-143-37260 |
| Popis: | SummaryRats were fed diets containing medium-chain triglycerides or corn oil and graded levels of cholestyramine to determine if fatty acid competition influences resin bile salt binding ability. When low levels of the resin were fed, MCT promoted a higher rate of bile salt excretion than did corn oil. With higher levels of resin, bile salt excretion apparently was limited by hepatic capacity for bile salt synthesis; animals fed corn oil had higher rates of bile salt excretion than those fed MCT. Rats fed dietary MCT had relatively greater amounts of taurine-conjugated bile salts in the duodenal bile than did rats fed dietary corn oil. Cholestyramine affected the bile salt composition of bile by increasing the relative amounts of glycine-trihydroxy bile salt, and decreasing the relative amounts of taurine-dihydroxy bile salt in the bile.The authors thank Messrs. D. A. Julow, W. T. Ellis, and L. M. Ottman for technical assistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|