From Rabbits to Humans: The Contributions of Dr. Theodore E. Woodward to Tularemia Research
| Autor: | Alan S. Cross, Frank M. Calia, Robert R. Edelman |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
complex mixtures Tularemia Animal model Animals Humans Medicine Francisella tularensis Ohio Infectivity Clinical Trials as Topic Maryland Zoonotic Infection biology Extramural business.industry Transmission (medicine) Prisoners History 20th Century respiratory system bacterial infections and mycoses medicine.disease biology.organism_classification Virology Tularemia vaccine Anti-Bacterial Agents Human Experimentation Infectious Diseases Bacterial Vaccines Immunology Rabbits business |
| Zdroj: | Clinical Infectious Diseases. 45:S61-S67 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/518150 |
| Popis: | Tularemia is an endemic zoonotic infection caused by Francisella tularensis, which primarily causes infection in humans who have handled contaminated animal tissue or have been bitten by infected arthropods. Because of its ease of dispersion and transmission and its high degree of infectivity, F. tularensis is also considered to be a bioterrorism agent. Consequently, there is renewed interest in the development of safe, effective measures, such as vaccines, to prevent the morbidity and mortality associated with aerosol exposure to F. tularensis. Current efforts, however, are hampered by the lack of an animal model that faithfully reproduces human infection. Employing a model of "induced human infection" with aerosol administration of F. tularensis, Dr. Theodore E. Woodward and colleagues pioneered the clinical studies of tularemia vaccines that form the basis for current tularemia vaccine research. |
| Databáze: | OpenAIRE |
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