Recommendations for biomarker testing in epithelial ovarian cancer: a National Consensus Statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology
Autor: | A. Oaknin, R. Guarch, P. Barretina, D. Hardisson, A. González-Martín, X. Matías-Guiu, A. Pérez-Fidalgo, B. Vieites, I. Romero, J. Palacios |
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Rok vydání: | 2017 |
Předmět: |
BRCA2 Protein
Ovarian Neoplasms 0301 basic medicine Cancer Research BRCA1 Protein General Medicine Carcinoma Ovarian Epithelial 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Mutation Biomarkers Tumor Humans Female Neoplasms Glandular and Epithelial Algorithms |
Zdroj: | CLINICAL & TRANSLATIONAL ONCOLOGY r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname |
ISSN: | 1699-3055 1699-048X |
Popis: | Because of advances in the understanding of histological and molecular characteristics in ovarian cancer, it is now possible to recognize the existence of five subtypes, which in turn has allowed a more refined therapeutic approach and better design of clinical trials. Each of these five subtypes has specific histological features and a particular biomarker expression, as well as mutations in different genes, some of which have prognostic and predictive value. CA125 and HE4 are examples of ovarian cancer biomarkers used in the diagnosis and follow-up of these malignancies. Currently, somatic or germinal mutations on BRCA1 and BRCA2 genes are the most important biomarkers in epithelial ovarian cancer having prognostic and predictive value. This article will review the histological and molecular characteristics of the five subtypes of ovarian cancer, describing the most important biomarkers and mutations that can guide in diagnosis, screening and tailored treatment strategy. |
Databáze: | OpenAIRE |
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