Effects of Teucrium divaricatum Heldr. ssp. divaricatum decoction on experimental ulcer in rats
| Autor: | Rokia Sanogo, Natalizia Miceli, A. d’Aquino, M. T. Monforte, Enza Maria Galati, Olga Tzakou, M. R. Mondello |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Gastric juices Teucrium divaricatum Heldr. ssp. divaricatum Decoction Pharmacognosy Acetylsalicylic acid- induced ulcer Gastric protection Transmission electronic microscopy Ulcer index law.invention Intragastric administration law Drug Discovery Animals Medicine Teucrium divaricatum Stomach Ulcer Rats Wistar Pharmacology Plants Medicinal Aspirin Traditional medicine Mediterranean Region Plant Extracts business.industry Anti-Inflammatory Agents Non-Steroidal food and beverages Anti-Ulcer Agents digestive system diseases Rats Microscopy Electron Gastric Mucosa Gastric acid business Phytotherapy |
| Zdroj: | Journal of Ethnopharmacology. 72:337-342 |
| ISSN: | 0378-8741 |
| Popis: | The effects of chronic intragastric administration of the aerial parts decoction of Teucrium divaricatum Heldr. ssp. divaricatum (Labiateae) on experimental acetylsalicylic acid (ASA)-induced ulcer were studied in rats. The ulcer index and histological mucosa regeneration were evaluated. The ulcer index significantly decreased (U.I. 1.7+/-1.5; P0.05) after treatment with a lyophilized decoction of T. divaricatum (500 mg/kg os), once daily for 7 days, compared to the control (U.I. 11.4+/-2.3). The ultrastructure modifications of gastric mucosa were observed by transmission electronic microscopy (TEM) confirming the antisecretory effect exercised by administration of the T. divaricatum decoction. Treatment with T. divaricatum seems to block up parietal cell acid secretion and to stimulate in the chief cells the formation of zymogen granules. |
| Databáze: | OpenAIRE |
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