Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration
| Autor: | Dikshya Bastakoty, Pampee P. Young |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Beta-catenin Review Biochemistry 03 medical and health sciences 0302 clinical medicine Fibrosis Genetics medicine Animals Humans Regeneration Molecular Biology Wnt Signaling Pathway beta Catenin Wound Healing biology Regeneration (biology) Wnt signaling pathway medicine.disease Embryonic stem cell Cell biology Wnt Proteins 030104 developmental biology 030220 oncology & carcinogenesis Catenin biology.protein Signal transduction Wound healing Biotechnology Signal Transduction |
| Zdroj: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(10) |
| ISSN: | 1530-6860 |
| Popis: | The Wnt/β-catenin pathway is an evolutionarily conserved set of signals with critical roles in embryonic and neonatal development across species. In mammals the pathway is quiescent in many organs. It is reactivated in response to injury and is reported to play complex and contrasting roles in promoting regeneration and fibrosis. We review the current understanding of the role of the Wnt/β-catenin pathway in injury of various mammalian organs and discuss the current advances and potential of Wnt inhibitory therapeutics toward promoting tissue regeneration and reducing fibrosis.-Bastakoty, D., Young, P. P. Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration. |
| Databáze: | OpenAIRE |
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