Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
| Autor: | A. Albuquerque, M. Barral Netto, I. L. Queiroz, Elisângela Vitória Adorno, Aldina Barral, S. A. Cardoso, Marilda Souza Goncalves, M.G. dos Reis, A.C. Strapazoni, Alexandre J. Santana, A. Zanetti |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Adolescent Physiology Hemoglobin Sickle Immunology Cell Population Biophysics Arterial Occlusive Diseases Anemia Sickle Cell Disease interleukin 8 sickle cell syndromes Biochemistry Pathogenesis Hemoglobins Risk Factors medicine Humans Interleukin 8 General Pharmacology Toxicology and Pharmaceutics Child education lcsh:QH301-705.5 lcsh:R5-920 education.field_of_study vaso-occlusive crisis business.industry General Neuroscience Interleukin-8 Significant difference Infant Syndrome Cell Biology General Medicine Middle Aged medicine.disease medicine.anatomical_structure lcsh:Biology (General) Child Preschool Female Hemoglobin lcsh:Medicine (General) business Vaso-occlusive crisis Biomarkers Brazil |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 10, Pages: 1309-1313, Published: OCT 2001 Brazilian Journal of Medical and Biological Research, Vol 34, Iss 10, Pp 1309-1313 (2001) Brazilian Journal of Medical and Biological Research v.34 n.10 2001 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| Popis: | Sickle cell disease has a worldwide distribution and is a public health problem in Brazil. Although vaso-occlusive crisis (VOC) is one of the most important clinical features of the disease, there are still several steps of its pathogenesis which are unknown. The increase of the chemotactic factor interleukin 8 (IL-8) has been reported to be involved in sickle cell disease crisis, but this has not been demonstrated conclusively. In the present study we analyzed serum IL-8 levels by ELISA and hematological parameters and hemoglobin patterns by standard techniques in 23 (21 SS and 2 SC) Brazilian patients with sickle cell syndromes during VOC caused by different inducing factors, 22 (21 SS and 1 SC) sickle cell patients out of crisis, and 11 healthy controls. Increased IL-8 levels were observed in 19 of 23 VOC patients (79.2%), 3 of them with more than 1,000 pg/ml. Seventeen of 22 (77.3%) non-crisis patients showed low IL-8 levels (less than 15 pg/ml). Healthy controls had low IL-8 levels. A significant difference in serum IL-8 levels was observed between crisis and non-crisis sickle cell patients (P |
| Databáze: | OpenAIRE |
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