α-synuclein as an emerging pathophysiological biomarker of Alzheimer’s disease
| Autor: | Maria Francesca Beatino, Ciro De Luca, Nicole Campese, Elisabetta Belli, Rebecca Piccarducci, Linda Giampietri, Claudia Martini, Giulio Perugi, Gabriele Siciliano, Roberto Ceravolo, Andrea Vergallo, Harald Hampel, Filippo Baldacci |
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| Přispěvatelé: | Beatino, Maria Francesca, De Luca, Ciro, Campese, Nicole, Belli, Elisabetta, Piccarducci, Rebecca, Giampietri, Linda, Martini, Claudia, Perugi, Giulio, Siciliano, Gabriele, Ceravolo, Roberto, Vergallo, Andrea, Hampel, Harald, Baldacci, Filippo |
| Rok vydání: | 2022 |
| Předmět: |
fluid biomarkers
Synucleinopathies alpha-synuclein precision medicine RT-QuIC Biomarker Pathology and Forensic Medicine Diagnosis Differential neurodegenerative disease PMCA nervous system Alzheimer Disease Genetics Humans Molecular Medicine neurodegenerative diseases Synucleinopathie Alzheimer’s disease fluid biomarker Molecular Biology Biomarkers Human |
| DOI: | 10.6084/m9.figshare.19722833.v1 |
| Popis: | α-syn aggregates represent the pathological hallmark of synucleinopathies as well as a frequent copathology (almost 1/3 of cases) in AD. Recent research indicates a potential role of α-syn species, measured in CSF with conventional analytical techniques, in the differential diagnosis between AD and synucleinopathies (such as DLB). Pioneering studies report the detection of α-syn in blood, however, conclusive investigations are controversial. Ultrasensitive seed amplification techniques, enabling the selective quantification of α-syn seeds, may represent an effective solution to identify the α-syn component in AD and facilitate a biomarker-guided stratification. We performed a PubMed-based review of the latest findings on α-syn-related biomarkers for AD, focusing on bodily fluids. A dissertation on the role of ultrasensitive seed amplification assays, detecting α-syn seeds from different biological samples, was conducted. α-syn may contribute to progressive AD neurodegeneration through cross-seeding especially with tau protein. Ultrasensitive seed amplification techniques may support a biomarker-drug co-development pathway and may be a pathophysiological candidate biomarker for the evolving ATX(N) system to classify AD and the spectrum of primary NDDs. This would contribute to a precise approach to AD, aimed at implementing disease-modifying treatments. |
| Databáze: | OpenAIRE |
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