Gata-3 and KI-67 expression in correlation with molecular subtypes of breast cancer
| Autor: | Berti Nelwan, M Husni Cangara, Syarifuddin Wahid, Upik A. Miskad, Rina Masadah |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Cancer Research Gene Expression Breast Neoplasms GATA3 Transcription Factor Correlation Breast cancer medicine Biomarkers Tumor Humans Retrospective Studies Paraffin Embedding biology business.industry Retrospective cohort study General Medicine Congresses as Topic Middle Aged medicine.disease Immunohistochemistry Ki-67 Antigen Oncology Hormone receptor Ki-67 biology.protein Cancer research Female Lymph Antibody business |
| Zdroj: | Breast disease. 40(S1) |
| ISSN: | 1558-1551 |
| Popis: | OBJECTIVES: This study aims to evaluate and compare four breast cancer subtypes defined by immunohistochemistry expression of ER, PR, and HER-2 in correlation with Ki-67 and GATA-3 expression. METHODS: Slides from 89 paraffin blocks of invasive breast cancer patients with four molecular subtypes based on HER-2, ER, and PR expression were then stained with Ki-67 and GATA-3 antibodies to evaluate their expression in correlation with molecular subtype and metastases to lymph nodes. RESULTS: This study was a retrospective study of 89 invasive breast cancers. Luminal A; Luminal B; HER2+; and triple-negative types were 35 (39.3%), 10 (11.2%), 27 (30.3%), and 17 (19.1%) samples. Expression of Ki-67 was increased in triple-negative (TN) tumor compared to non-triple-negative (non-TN) tumor subtypes (p |
| Databáze: | OpenAIRE |
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