Combined Hyperinsulinemia and Hyperglycemia, But Not Hyperinsulinemia Alone, Suppress Human Skeletal Muscle Lipolytic Activityin Vivo
| Autor: | Jan Bolinder, Staffan Enoksson, Stefan Sjöberg, Veronica Qvisth, E Hagström-Toft, Robert S. Sherwin |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Glycerol medicine.medical_specialty Lipolysis Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Adipose tissue Biology Biochemistry Hypoinsulinemia Endocrinology Hyperinsulinism Internal medicine medicine Hyperinsulinemia Humans Muscle Skeletal Lipoprotein lipase Insulin Biochemistry (medical) nutritional and metabolic diseases Skeletal muscle Middle Aged medicine.disease Lipoprotein Lipase medicine.anatomical_structure Adipose Tissue Regional Blood Flow Hyperglycemia |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 89:4693-4700 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2003-030656 |
| Popis: | Effects of circulating insulin and glucose concentrations on skeletal muscle and adipose tissue lipolytic activity were investigated in 10 type 1 diabetes patients with no endogenous insulin secretion. Microdialysis measurements of interstitial glycerol and determination of fractional glycerol release were carried out during standardized combinations of relative hypoinsulinemia/moderate hyperglycemia (11 mmol/liter), hyperinsulinemia/ normoglycemia (5 mmol/liter), and hyperinsulinemia/moderate hyperglycemia, respectively. Local tissue blood flow rates were measured with the (133)Xe clearance technique. In response to the change from hypo- to hyperinsulinemia, the fractional release of glycerol decreased from 159.6 +/- 17.8 to 85.1 +/- 13.7 micromol/liter (P < 0.0001) in adipose tissue, whereas it remained unchanged in skeletal muscle (44.6 +/- 6.4 vs. 36.0 +/- 7.4 micromol/liter; not significant). When hyperinsulinemia was combined with hyperglycemia, fractional glycerol release was further reduced in adipose tissue (64.5 +/- 12.2 micromol/liter; P < 0.05), and in this situation it was also markedly decreased in skeletal muscle (18.1 +/- 4.8 micromol/liter; P < 0.0001). Skeletal muscle blood flow was unaltered over the respective study periods. Adipose tissue blood flow decreased by 50% in response to hyperinsulinemia (P < 0.0005), but no further change was seen when hyperinsulinemia was combined with hyperglycemia. It is concluded that in patients with type 1 diabetes, insulin does not exert an antilipolytic effect in skeletal muscle during normoglycemia. However, in response to combined hyperinsulinemia and hyperglycemia, the lipolytic activity in skeletal muscle is restrained in a similar way as in adipose tissue. This may be explained by a glucose-mediated potentiation of the antilipolytic effectiveness of insulin. |
| Databáze: | OpenAIRE |
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