Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor
| Autor: | Dragoslav P. Milosevic, Udo Schumacher, Dragan Kalem, Thomas Rösch, Mihailo D. Rabasović, Svetlana Z. Jovanić, Petar Svorcan, Predrag Erceg, Sanja Despotović, Dejan Pantelić, Živana Milićević, Novica M. Milićević, Ivana M. Lalić, Aleksandar J. Krmpot, Nebojsa Despotovic, Srđan Marković, Sebastian Ullrich, Gordana Mihajlovic |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Stromal cell Carcinogenesis Adenocarcinoma Extracellular matrix 03 medical and health sciences 0302 clinical medicine Intestinal mucosa medicine Lymphatic vessel Humans Intestinal Mucosa RC254-282 Aged Lamina propria Mucous Membrane Rectal Neoplasms business.industry Ground substance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Mucous membrane General Medicine Extracellular Matrix 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Reticular connective tissue Disease Progression Blood Vessels Female business |
| Zdroj: | Tumor Biology, Vol 39 (2017) |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.1177/1010428317711654 |
| Popis: | In recent years, it has been demonstrated that malignancy arises and advances through the molecular interplay between tumor cells and non-malignant elements of the tumor stroma, that is, fibroblasts and extracellular matrix. However, in contrast to the mounting evidence about the role of tumor stroma in the genesis and progression of the malignant disease, there are very few data regarding the uninvolved stromal tissue in the remote surrounding of the tumor. Using the objective morphometric approach in patients with adenocarcinoma, we demonstrate the remodeling of extracellular matrix of the lamina propria in the uninvolved rectal mucosa 10 and 20 cm away from the neoplasm. We show that the representation of basic extracellular matrix constituents (reticular and collagen fibers and ground substance) is decreased. Also, the diameter of empty spaces that appear within the extracellular matrix of the lamina propria is increased. These spaces do not represent the blood or lymphatic vessel elements. Very likely, they reflect the development of tissue edema in the remote, uninvolved lamina propria of the mucosa in patients with the malignant tumor of the rectum. We hypothesize that the remodeling of extracellular matrix in lamina propria of the rectal mucosa may increase its stiffness, modulating the mechano-signal transduction, and thus promote the progression of the malignant disease. |
| Databáze: | OpenAIRE |
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