Presence of Mycobacterium leprae in epidermal cells of lepromatous skin and its significance
| Autor: | Jasmita Satapathy, Charles K. Job, Bikash Ranjan Kar |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Leprostatic Agents Dermatology Dapsone Risk Assessment Severity of Illness Index Drug Administration Schedule Recurrence Biopsy Medicine Humans Mycobacterium leprae Lepromatous leprosy integumentary system biology medicine.diagnostic_test Epidermis (botany) Dose-Response Relationship Drug business.industry Biopsy Needle RELAPSED DISEASE Middle Aged biology.organism_classification medicine.disease Immunohistochemistry Leprosy Lepromatous Infectious Diseases Treatment Outcome Drug Therapy Combination Leprosy business medicine.drug Follow-Up Studies |
| Zdroj: | Indian journal of dermatology, venereology and leprology. 71(4) |
| ISSN: | 0378-6323 |
| Popis: | A 49-year-old man with lepromatous leprosy treated with dapsone monotherapy for 12 years (1967 to 1979) reported in the hospital in 2003, with relapsed disease. A slit skin smear showed a bacteriological index of 4+. Biopsies from skin lesions before and after anti-leprosy therapy showed features of lepromatous leprosy. Both biopsies showed unusual features of bacillary clumps in epidermal cells demonstrating clearly that dissemination of M. leprae can take place even through unbroken skin. The presence of lepra bacilli in clumps in the epidermis is an indicator that the skin is a potential route of transmission of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|