Prognosis of Primary Papillary Ta Grade 3 Bladder Cancer in the Non-muscle-invasive Spectrum

Autor: Irene J. Beijert, Anouk E. Hentschel, Johannes Bründl, Eva M. Compérat, Karin Plass, Oscar Rodríguez, Jose D. Subiela Henríquez, Virginia Hernández, Enrique de la Peña, Isabel Alemany, Diana Turturica, Francesca Pisano, Francesco Soria, Otakar Čapoun, Lenka Bauerová, Michael Pešl, H. Maxim Bruins, Willemien Runneboom, Sonja Herdegen, Johannes Breyer, Antonin Brisuda, Ana Calatrava, José Rubio-Briones, Maximilian Seles, Sebastian Mannweiler, Judith Bosschieter, Venkata R.M. Kusuma, David Ashabere, Nicolai Huebner, Juliette Cotte, Laura S. Mertens, Francesco Claps, Alexandra Masson-Lecomte, Fredrik Liedberg, Daniel Cohen, Luca Lunelli, Olivier Cussenot, Soha El Sheikh, Dimitrios Volanis, Jean-François Côté, Morgan Rouprêt, Andrea Haitel, Shahrokh F. Shariat, A. Hugh Mostafid, Jakko A. Nieuwenhuijzen, Richard Zigeuner, Jose L. Dominguez-Escrig, Jaromir Hacek, Alexandre R. Zlotta, Maximilian Burger, Matthias Evert, Christina A. Hulsbergen-van de Kaa, Antoine G. van der Heijden, Lambertus A.L.M. Kiemeney, Viktor Soukup, Luca Molinaro, Paolo Gontero, Carlos Llorente, Ferran Algaba, Joan Palou, James N'Dow, Maria J. Ribal, Theo H. van der Kwast, Marko Babjuk, Richard J. Sylvester, Bas.W.G. van Rhijn
Přispěvatelé: Beijert, Irene J, Hentschel, Anouk E, Bründl, Johanne, Compérat, Eva M, Plass, Karin, Rodríguez, Oscar, Subiela Henríquez, Jose D, Hernández, Virginia, de la Peña, Enrique, Alemany, Isabel, Turturica, Diana, Pisano, Francesca, Soria, Francesco, Čapoun, Otakar, Bauerová, Lenka, Pešl, Michael, Bruins, H Maxim, Runneboom, Willemien, Herdegen, Sonja, Breyer, Johanne, Brisuda, Antonin, Calatrava, Ana, Rubio-Briones, José, Seles, Maximilian, Mannweiler, Sebastian, Bosschieter, Judith, Kusuma, Venkata R M, Ashabere, David, Huebner, Nicolai, Cotte, Juliette, Mertens, Laura S, Claps, Francesco, Masson-Lecomte, Alexandra, Liedberg, Fredrik, Cohen, Daniel, Lunelli, Luca, Cussenot, Olivier, El Sheikh, Soha, Volanis, Dimitrio, Côté, Jean-Françoi, Rouprêt, Morgan, Haitel, Andrea, Shariat, Shahrokh F, Mostafid, A Hugh, Nieuwenhuijzen, Jakko A, Zigeuner, Richard, Dominguez-Escrig, Jose L, Hacek, Jaromir, Zlotta, Alexandre R, Burger, Maximilian, Evert, Matthia, Hulsbergen-van de Kaa, Christina A, van der Heijden, Antoine G, Kiemeney, Lambertus A L M, Soukup, Viktor, Molinaro, Luca, Gontero, Paolo, Llorente, Carlo, Algaba, Ferran, Palou, Joan, N'Dow, Jame, Ribal, Maria J, van der Kwast, Theo H, Babjuk, Marko, Sylvester, Richard J, van Rhijn, Bas W G, Urology, CCA - Cancer Treatment and quality of life, CCA - Imaging and biomarkers, Other Research
Rok vydání: 2023
Předmět:
Zdroj: European Urology Oncology, 6, 2, pp. 214-221
Beijert, I J, Hentschel, A E, Bründl, J, Compérat, E M, Plass, K, Rodríguez, O, Subiela Henríquez, J D, Hernández, V, de la Peña, E, Alemany, I, Turturica, D, Pisano, F, Soria, F, Čapoun, O, Bauerová, L, Pešl, M, Bruins, H M, Runneboom, W, Herdegen, S, Breyer, J, Brisuda, A, Calatrava, A, Rubio-Briones, J, Seles, M, Mannweiler, S, Bosschieter, J, Kusuma, V R M, Ashabere, D, Huebner, N, Cotte, J, Mertens, L S, Claps, F, Masson-Lecomte, A, Liedberg, F, Cohen, D, Lunelli, L, Cussenot, O, el Sheikh, S, Volanis, D, Côté, J-F, Rouprêt, M, Haitel, A, Shariat, S F, Mostafid, A H, Nieuwenhuijzen, J A, Zigeuner, R, Dominguez-Escrig, J L, Hacek, J, Zlotta, A R, Burger, M, Evert, M, Hulsbergen-van de Kaa, C A, van der Heijden, A G, Kiemeney, L A L M, Soukup, V, Molinaro, L, Gontero, P, Llorente, C, Algaba, F, Palou, J, N'Dow, J, Ribal, M J, van der Kwast, T H, Babjuk, M, Sylvester, R J & van Rhijn, B W G 2023, ' Prognosis of Primary Papillary Ta Grade 3 Bladder Cancer in the Non-muscle-invasive Spectrum ', European Urology Oncology, vol. 6, no. 2, pp. 214-221 . https://doi.org/10.1016/j.euo.2023.01.004
European Urology Oncology, 6(2), 214-221. Elsevier BV
ISSN: 2588-9311
DOI: 10.1016/j.euo.2023.01.004
Popis: Contains fulltext : 294430.pdf (Publisher’s version ) (Open Access) BACKGROUND: Ta grade 3 (G3) non-muscle-invasive bladder cancer (NMIBC) is a relatively rare diagnosis with an ambiguous character owing to the presence of an aggressive G3 component together with the lower malignant potential of the Ta component. The European Association of Urology (EAU) NMIBC guidelines recently changed the risk stratification for Ta G3 from high risk to intermediate, high, or very high risk. However, prognostic studies on Ta G3 carcinomas are limited and inconclusive. OBJECTIVE: To evaluate the prognostic value of categorizing Ta G3 compared to Ta G2 and T1 G3 carcinomas. DESIGN, SETTING, AND PARTICIPANTS: Individual patient data for 5170 primary Ta-T1 bladder tumors from 17 hospitals were analyzed. Transurethral resection of the tumor was performed between 1990 and 2018. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Time to recurrence and time to progression were analyzed using cumulative incidence functions, log-rank tests, and multivariable Cox-regression models with interaction terms stratified by institution. RESULTS AND LIMITATIONS: Ta G3 represented 7.5% (387/5170) of Ta-T1 carcinomas of which 42% were classified as intermediate risk. Time to recurrence did not differ between Ta G3 and Ta G2 (p = 0.9) or T1 G3 (p = 0.4). Progression at 5 yr occurred for 3.6% (95% confidence interval [CI] 2.7-4.8%) of Ta G2, 13% (95% CI 9.3-17%) of Ta G3, and 20% (95% CI 17-23%) of T1 G3 carcinomas. Time to progression for Ta G3 was shorter than for Ta G2 (p
Databáze: OpenAIRE
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