Hepatocyte growth factor as a potential index of complication in diabetes mellitus
| Autor: | Shigefumi Nakamura, Ryuichi Morishita, Atsushi Moriguchi, Yoshikage Yo, Yoshio Nakamura, Shin-ichiro Hayashi, Keiko Matsumoto, Kunio Matsumoto, Toshikazu Nakamura, Jitsuo Higaki, Toshio Ogihara |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Physiology Vasodilation Kidney Mice Diabetes mellitus Internal medicine Internal Medicine medicine Animals Humans Endothelial dysfunction Macrovascular disease Glycated Hemoglobin Hepatocyte Growth Factor business.industry Myocardium Kidney metabolism Middle Aged medicine.disease Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Endocrinology Diabetes Mellitus Type 2 Hypertension Female Hepatocyte growth factor Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Hypertension. 16:2019-2026 |
| ISSN: | 0263-6352 |
| Popis: | Objective Diabetes mellitus (DM), characterized by the premature development of microvascular and macrovascular disease, shows a loss of vasodilatory properties of resistance vessels. However, the mechanisms of endothelial dysfunction in diabetes have not yet been clarified. Hepatocyte growth factor (HGF) in vascular cells was down-regulated by high glucose levels, potentially accelerating the endothelial dysfunction in DM. In this study, the serum HGF level was measured to investigate further the role of HGF in DM. Methods Tissue and circulating HGF levels were measured in the KKA y mouse, a rodent model of non-insulin-dependent diabetes mellitus (NIDDM), and lean C57 BL control mice. Then, serum HGF concentrations were measured in NIDDM patients without liver, kidney or lung damage. For the study of serum HGF concentration, 30 normotensive and age-matched 58 DM patients were studied. The 58 DM patients were divided into 26 patients without hypertension and 32 patients with hypertension [22 patients without hypertensive complications (WHO I) and 10 patients with hypertensive complications (WHO II + III)]. Results The serum HGF concentration in KKA y mice was significantly lower than that in control mice (P< 0.01), at 14 weeks of age when they exhibit features of diabetes. Similarly, tissue HGF concentrations in the heart and kidney were decreased significantly in KKA y mice compared with control C57 BL mice (P< 0.05). The serum HGF concentration showed a significant negative correlation with hemoglobin (Hb) A ic concentration (P< 0.01, r= -0.41). Since the serum HGF concentration is a potential index of the severity of hypertension, the serum levels of HGF in DM patients without and with hypertension were examined. The serum HGF concentration in DM patients without hypertension was significantly lower than that in normal subjects (P |
| Databáze: | OpenAIRE |
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