Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT

Autor: Srinivas R. Sadda, Anmol A. Pardeshi, Jong Yeon Lee, Benjamin Y. Xu, Giulia Corradetti, Li-Xia Zhang, Alex S. Huang, Shuang Chen, Vikas Chopra, Abe Song, Fei Yu, William Sultan, Xiaobin Xie
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Aging
genetic structures
Intraclass correlation
Scleral spur
Diagnostic Radiology
Cornea
Mathematical and Statistical Techniques
Medicine and Health Sciences
Medicine
Prospective Studies
Tomography
Multidisciplinary
Eye Lens
Radiology and Imaging
Statistics
Age Factors
Repeatability
Eye Muscles
Muscle Analysis
Middle Aged
medicine.anatomical_structure
Bioassays and Physiological Analysis
Biometrics
Lens (anatomy)
Physical Sciences
Regression Analysis
Female
Anatomy
Tomography
Optical Coherence
Research Article
Adult
medicine.medical_specialty
Biometry
Imaging Techniques
Ocular Anatomy
Science
Linear Regression Analysis
Research and Analysis Methods
Ciliary body
Anterior Eye Segment
Ocular System
Diagnostic Medicine
Ophthalmology
Computational Techniques
Humans
Statistical Methods
Aged
Reproducibility
business.industry
Reproducibility of Results
Biology and Life Sciences
eye diseases
Ciliary muscle
Eyes
business
Head
Mathematics
Zdroj: PLoS ONE, Vol 15, Iss 10, p e0240110 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: PurposeTo assess the effects of age and refractive status on anterior segment anatomical structures, including the ciliary body, using a new swept-source anterior segment optical coherence tomography (AS-OCT) device.MethodsThis prospective observational study included 63 healthy volunteers (mean age: 44.2 years). Images of the anterior segment were obtained using a new swept-source AS-OCT (ANTERION, Heidelberg Engineering GmbH, Heidelberg, Germany) with tracking and image averaging from the right eye of all participants. Repeatability as well as inter- and intra-observer reliability of biometric measurements were evaluated. The impact of image tracking and averaging on ciliary muscle measurements was tested. Univariate and multivariable statistical models were developed to evaluate the relationship of age and refractive status on anterior segment biometric measurements.ResultsFor all test-retest repeatability and inter- and intra-observer reproducibility of swept-source AS-OCT measurements, high intraclass correlation (ICC) was noted (0.88-1.00). The nasal maximum ciliary muscle thickness (CMTMAX) and distance between scleral spur to the thickest point of the ciliary muscle (SSMAX) were larger than those on the temporal side (pConclusionsRepeatability and reproducibility of biometric measurements using the ANTERION AS-OCT were excellent. Image averaging improved the accuracy of ciliary muscle measurements. The device produced measurements of biometric parameters that described superficial and deep structures including the ciliary body and full lens thickness from a single image.
Databáze: OpenAIRE
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