Effects of tachykinins on inositol phospholipid hydrolysis in slices of hamster urinary bladder
| Autor: | K. J. Watling, B. J. Williams, N. Suman-Chauhan, N. R. Curtis, David R. Bristow |
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| Rok vydání: | 1987 |
| Předmět: |
Atropine
medicine.medical_specialty Inositol Phosphates Urinary Bladder Inositol monophosphatase Hamster Nerve Tissue Proteins Substance P In Vitro Techniques complex mixtures chemistry.chemical_compound Eledoisin Cricetinae Internal medicine medicine Animals Inositol Receptors Tachykinin Pharmacology Mesocricetus biology Chemistry Hydrolysis musculoskeletal neural and ocular physiology Receptors Neurotransmitter Kassinin Endocrinology biology.protein Carbachol Sugar Phosphates Neurokinin A Tachykinin receptor Research Article |
| Zdroj: | British Journal of Pharmacology. 90:211-217 |
| ISSN: | 0007-1188 |
| Popis: | Tachykinin-stimulated inositol phospholipid hydrolysis was examined in slices of hamster urinary bladder. In the presence of lithium, to inhibit inositol monophosphatase activity, substance P, eledoisin and related tachykinins induced large, dose-dependent increases in [3H]-inositol monophosphate accumulation. The responses to substance P and eledoisin were not antagonized by the cholinoceptor antagonist, atropine. The rank order of potency for various tachykinins was kassinin greater than neurokinin A greater than neurokinin B greater than eledoisin greater than physaelamin greater than substance P greater than substance P methyl ester. The synthetic analogue [p-Glu6, D-Pro9]SP (6-11) was considerably more potent than its L-prolyl stereoisomer at stimulating inositol phospholipid hydrolysis. These results suggest that in the hamster urinary bladder, tachykinin-induced inositol phospholipid breakdown is mediated via tachykinin receptors of the SP-E type, as opposed to the SP-P type. |
| Databáze: | OpenAIRE |
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