The Russian Human Radiobiological Tissue Repository: A Unique Resource for Studies of Plutonium-Exposed Workers
Autor: | Valentina Revina, Christopher A. Loffredo, Svetlana Sokolova, David S. Goerlitz, Mariya Zakharova, Evgeniya Kirillova, Leonidas Leondaridis |
---|---|
Rok vydání: | 2016 |
Předmět: |
Paper
medicine.medical_specialty Tissue Repository Resource (biology) Medical information Tissue Banks Russia 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Informed consent Occupational Exposure Radiation Ionizing Environmental health medicine Humans Radiology Nuclear Medicine and imaging Medical physics Radiation Radiological and Ultrasound Technology Health consequences business.industry Public Health Environmental and Occupational Health Radiobiology General Medicine Plutonium 030220 oncology & carcinogenesis Tissue bank Occupational exposure business |
Zdroj: | Radiation Protection Dosimetry. 173:10-15 |
ISSN: | 1742-3406 0144-8420 |
Popis: | The Russian Radiobiological Human Tissue Repository (RHTR) at the Southern Urals Biophysics Institute in Ozyorsk, Russia, was established to collect and store biospecimens supporting research on health consequences of chronic, low-dose radiation exposures. The purpose of this paper is to describe the RHTR resources and the availability of high-quality biological specimens. RHTR has enrolled two groups of subjects from 1951 to the present time: exposed workers at the Mayak Production Association facilities and residents of Ozyorsk who were never occupationally exposed to ionizing radiation (controls). Biospecimens are collected with informed consent of participants and are annotated with demographic, occupational, dosimetry and medical information. To date, 900 individuals have provided surgical tissues and 1000 have provided autopsy tissues. Blood samples are also collected and stored. Familial DNA is available from parent–offspring triads. Biospecimens and annotated data are available to interested scientists worldwide, via the RHTR website. |
Databáze: | OpenAIRE |
Externí odkaz: |