Sleep apnea in precapillary pulmonary hypertension
| Autor: | Rio Dumitrascu, Werner Seeger, Konstantin Mayer, Richard Schulz, Jan Eckermann, Jörg Heitmann, Hossein Ardeschir Ghofrani, Henning Tiede, Frank Reichenberger |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cardiac Catheterization Pulmonary Circulation Central sleep apnea Hypertension Pulmonary Polysomnography Population Disorders of Excessive Somnolence Severity of Illness Index Body Mass Index Risk Factors Severity of illness Prevalence medicine Humans Prospective Studies education Aged Sleep Apnea Obstructive education.field_of_study Hypocapnia medicine.diagnostic_test business.industry Sleep apnea General Medicine Middle Aged medicine.disease Pulmonary hypertension Capillaries respiratory tract diseases Obstructive sleep apnea Anesthesia Female business Body mass index |
| Zdroj: | Sleep Medicine. 14:247-251 |
| ISSN: | 1389-9457 |
| DOI: | 10.1016/j.sleep.2012.11.013 |
| Popis: | Objectives Pilot studies have described the occurrence of sleep apnea in patients with precapillary pulmonary hypertension (PH). However, there are no data on the prevalence of sleep-related breathing disorders in larger patient cohorts with PH. Methods 169 patients with a diagnosis of PH confirmed by right heart catheterisation and clinically stable in NYHA classes II or III were prospectively investigated by polygraphy ( n =105 females, mean age: 61.3years, mean body mass index: 27.2kg/m 2 ). Recruitment was independent of sleep-related symptoms and the use of vasodilator drugs or nasal oxygen. Results 45 patients (i.e. 26.6%) had an apnea–hypopnea-index (AHI) >10/h. Of these, 27 patients (i.e. 16%) had obstructive sleep apnea (OSA) and 18 patients (i.e. 10.6%) had central sleep apnea (CSA). The mean AHI was 20/hour. As a polygraphy had been performed with nasal oxygen in half of the patients without evidence for sleep apnea, the frequency of CSA was probably underestimated. Patients with OSA were characterized by male gender and higher body mass index whereas, those with CSA were older and hypocapnic. Conclusions At least every fourth patient with PH suffers from mild-to-moderate sleep apnea. Considering the anthropometric characteristics of the patients studied, the prevalence of both OSA and CSA seem to be higher in PH than in the general population. |
| Databáze: | OpenAIRE |
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