Effect of Transcutaneous Electrical Stimulation of Nerves on Blood Pressure and Blood Content of Neuropeptide CGRP and Nitric Oxide in Hypertensive Rats with Metabolic Disturbances
| Autor: | Tatyana A. Korolenko, V. K. Spiridonov, Z S Tolochko |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Calcitonin Gene-Related Peptide Blood Pressure Stimulation Fructose Calcitonin gene-related peptide Nitric Oxide Transcutaneous electrical nerve stimulation General Biochemistry Genetics and Molecular Biology Nitric oxide law.invention Impaired glucose tolerance 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law Internal medicine medicine Animals Rats Wistar business.industry Neuropeptides General Medicine medicine.disease Rats 030104 developmental biology Endocrinology Blood pressure chemistry Hypertension Transcutaneous Electric Nerve Stimulation Metabolic syndrome business 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 166:436-439 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04367-6 |
| Popis: | The development of arterial hypertension in male Wistar rats with fructose-induced metabolic syndrome (12.5% of fructose solution as the only drinking source for 10 weeks) along with impaired glucose tolerance and increased serum concentration of triglycerides and LPO products caused a decrease in the content of serum blood calcitonin gene-related peptide (CGRP). Low-frequency transcutaneous electrical nerve stimulation (1 mA, 2 Hz, 10 min daily for 2 weeks) performed in 8 weeks after the beginning of fructose treatment reduced systolic BP and serum concentration of triglycerides and LPO produces and improved glucose tolerance. After stimulation, CGRP content in rats maintained on fructose diet returned to normal values and the content of nitric oxide metabolites increased. We hypothesize that CGRP and nitric oxide are involved in mechanisms mediating the therapeutic effect of low-frequency transcutaneous electrical nerve stimulation on arterial hypertension developing in metabolic syndrome. |
| Databáze: | OpenAIRE |
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