The role of trophoblastic epigenetic reprogrammation in benign tumor cells on malignant progression: A molecular hypothesis
| Autor: | Kevin Doello |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell type Placenta Antineoplastic Agents Biology Epigenesis Genetic Metastasis Diagnosis Differential 03 medical and health sciences Insulin-Like Growth Factor II Pregnancy Neoplasms Biomarkers Tumor medicine Humans Benign tumor cells Neoplasm Invasiveness Epigenetics Neoplasm Metastasis Gene Trophoblast Cancer General Medicine Models Theoretical medicine.disease Phenotype Trophoblasts 030104 developmental biology medicine.anatomical_structure Mutation Disease Progression Cancer research Female Immunosuppressive Agents |
| Zdroj: | Medical Hypotheses. 113:68-71 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2018.02.019 |
| Popis: | Cancer tissues and placental ones share many properties such as invasiveness, metastasis and local immunosuppressive effects. The goal of the present article is to hypothesize a theory about cancer origin that links placental and cancerous tissues at molecular level. This hypothesis explain that cancer origin could be due to low hypoxic conditions in the peripheral zones of benign tumors which might up-regulate the expression of IGF2, and, consequently, trophoblastic genes. In fact, many phenotypic characteristics and molecular markers are shared between these two cell types (cancerous and trophoblastics ones), providing evidences to support this hypothesis. As a consequence, it could be interesting to demonstrate whether cancer start with a cellular reprogrammation towards a trophoblastic fate in order to design new antitumoral strategies focused on this fact. |
| Databáze: | OpenAIRE |
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