Influence of early-life parental severe life events on the risk of type 1 diabetes in children: the DiPiS study

Autor: Markus, Lundgren, Katarina, Ellström, Helena, Elding Larsson, J, Neiderud
Rok vydání: 2018
Předmět:
Male
Parents
Endocrinology
Diabetes and Metabolism
Severity of Illness Index
Pediatrics
Cohort Studies
0302 clinical medicine
Endocrinology
Diabetes mellitus
Pregnancy
Risk Factors
Surveys and Questionnaires
Prospective cohort study
Child
education.field_of_study
Hazard ratio
General Medicine
Child
Preschool
Prenatal Exposure Delayed Effects
Cohort
Female
Original Article
Disease Susceptibility
Cohort study
Type 1
Adult
medicine.medical_specialty
Adolescent
Population
030209 endocrinology & metabolism
Stress
Autoimmune Diseases
03 medical and health sciences
Young Adult
Internal medicine
Internal Medicine
medicine
Humans
education
Sweden
Type 1 diabetes
Proportional hazards model
business.industry
Infant
Newborn
Infant
medicine.disease
Pregnancy Complications
Diabetes Mellitus
Type 1
Psychological
business
Prospective studies
030217 neurology & neurosurgery
Stress
Psychological
Zdroj: Acta Diabetologica
ISSN: 1432-5233
Popis: Aims Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study. Methods Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n = 3784) from the DiPiS cohort of children were included in the analysis. SLEs were analyzed both by groups and as a combined variable. A Cox proportional hazards model was used to calculate hazard ratios (HRs) for T1D diagnosis for the total cohort and for the HLA-DQ2/8 high-risk population. Affected first-degree relatives, HLA-DQ risk group, paternal education level, and parents’ country of birth were included as covariates. Results There was a significantly increased risk of T1D in children with SLEs occurring during the child’s first 2 years of life for both the total cohort (HR 1.67; 95% CI 1.1, 2.7; p = 0.03) and the DQ2/8 cohort (HR 2.2; 95% CI 1.1, 4.2; p = 0.018). Subgroup analysis of events related to unemployment, divorce, or family conflict showed a significant hazard for these events occurring both during and after pregnancy in the DQ2/8 cohort (HR 2.17; 95% CI 1.1, 4.3; p = 0.03 and HR 4.98; 95% CI 2.3, 11; p
Databáze: OpenAIRE
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