Long-Term Outcomes Using Electron IOERT APBI for Early Stage Breast Cancer: The Verona University Hospital Experience
| Autor: | Davide Lombardi, Francesca Pellini, G. Rossi, Renzo Mazzarotto, Maria Grazia Giri, Paola Del Bianco, Alessandro Muraglia, Mario Romano, Carlo Cavedon, Stefania Guariglia, N.L.V. Cernusco, Giovanni Paolo Pollini |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty medicine.medical_treatment Phases of clinical research Breast Neoplasms Electrons Mastectomy Segmental Quadrant (abdomen) Breast cancer medicine Long term outcomes Humans Stage (cooking) Neoplasm Staging Performance status business.industry Radiotherapy Dosage Middle Aged medicine.disease University hospital Radiation therapy Treatment Outcome Oncology Italy Female Radiotherapy Adjuvant Radiology business |
| Zdroj: | Clinical breast cancer. 22(2) |
| ISSN: | 1938-0666 |
| Popis: | Abstarct Methods and Materials From July 2006 to December 2015, 295 patients suitable for breast-conserving therapy entered a single-arm phase II study and were treated with IOERT as radical treatment. Inclusion criteria were age >50, postmenopausal status, cT1N0M0 stage, grade G1-G2, positive estrogen receptor status; unicentric and unifocal disease, histologically proven invasive ductal carcinoma no previous breast irradiation, good performance status. Results With a median follow-up of 7.1 years (95% CI, 6.5;7.4) 6 women (2.0%) experienced a true local recurrence (reappearance of the tumour in the same quadrant). Five-year overall survival and local recurrence-free survival were 96% (95% CI, 92.9;97.8) and 94.9% (95% CI, 91.6;97.0) respectively. Conclusion Our trial suggests that, in highly selected early stage breast cancers, a single-dose IOERT can be safely delivered with excellent results and very low long-term recurrence rates. |
| Databáze: | OpenAIRE |
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