Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with infection at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Autor: Tadesse Eguale, Admasu Tenna, Getachew Tadesse, Haile Alemayehu, Sileshi Tadesse, Tefaye Sisay Tessema, Workineh Shibeshi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Staphylococcus aureus
Adolescent
030106 microbiology
Ear infection
Drug resistance
Microbial Sensitivity Tests
medicine.disease_cause
Staphylococcal infections
Hospitals
University
Tertiary Care Centers
03 medical and health sciences
Young Adult
0302 clinical medicine
Antibiotic resistance
lcsh:RA1190-1270
Internal medicine
Drug Resistance
Multiple
Bacterial
Medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Child
Otitis media
lcsh:Toxicology. Poisons
Pharmacology
business.industry
lcsh:RM1-950
Clindamycin
Staphylococcal Infections
medicine.disease
Methicillin-resistant Staphylococcus aureus
Trimethoprim
Anti-Bacterial Agents
lcsh:Therapeutics. Pharmacology
Female
Ethiopia
business
Surgical site infection
medicine.drug
Research Article
Methicillin resistant Staphylococcus aureus
Zdroj: BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-8 (2018)
BMC Pharmacology & Toxicology
ISSN: 2050-6511
DOI: 10.1186/s40360-018-0210-9
Popis: Background Staphylococcus aureus is one of the major pathogens of public health importance responsible for various forms of infection. Development of resistance to commonly used antimicrobials limited treatment options against infections due to this pathogen. Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with surgical site infection and ear infection and corresponding nasal swab was investigated in Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia. Methods Wound and corresponding nasal swabs from patients with surgical site infection from general surgery ward (n = 14), orthopedic ward (n = 21) and those with otitis media (n = 59) from Ear Nose and Throat (ENT) ward were cultured for S. aureus isolation according to standard procedures from December 2013 to June 2014. Isolates were investigated for susceptibility to panel of 17 antimicrobials using Kirby Bauer disc diffusion assay. Susceptibility to methicillin was phenotypically determined based on sensitivity of isolates to cefoxitin and oxacillin. Results A total of 79 S. aureus isolates were recovered from 54(57.4%) of patients. The isolates were resistant to ampicillin (100%), oxacillin and cefoxitin (68.4%, each), clindamycin (63.3%), cephalothin (59.5%), tetracycline (57%), sulfamethoxazole + trimethoprim and bacitracin (53.2%, each), and erythromycin (51.9%). Resistance to two or more antimicrobials was recorded in 74 (95%) of the isolates, while resistance to 3 or more antimicrobials was detected in 65(82.3%) of the isolates. Fifty-four (68.4%) of the isolates were methicillin resistant S. aureus (MRSA). Rate of occurrence of MRSA was more common among isolates from surgical wards (p
Databáze: OpenAIRE
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