Changes of synovial fluid biomarker levels after opening wedge high tibial osteotomy in patients with knee osteoarthritis
| Autor: | Joji Matsubara, Yutaka Inaba, Ken Kumagai, Shuntaro Nejima, Hiroshi Fujimaki, Shunsuke Yamada |
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| Rok vydání: | 2021 |
| Předmět: |
Male
musculoskeletal diseases 0301 basic medicine medicine.medical_specialty Biomedical Engineering Urology Osteoarthritis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology High tibial osteotomy Synovial Fluid medicine Humans Synovial fluid Orthopedics and Sports Medicine Aged 030203 arthritis & rheumatology Cartilage oligomeric matrix protein Tibia biology business.industry Interleukins Cartilage Osteoarthritis Knee musculoskeletal system medicine.disease biology.organism_classification Osteotomy Vascular endothelial growth factor Valgus 030104 developmental biology medicine.anatomical_structure chemistry Metalloproteases biology.protein Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Osteoarthritis and Cartilage. 29:1020-1028 |
| ISSN: | 1063-4584 |
| Popis: | The purpose of this study was to evaluate the effects of high tibial osteotomy (HTO) on the biological status of knee osteoarthritis (OA) using joint markers in synovial fluid (SF). Fifty patients with medial compartmental OA of the knee who underwent opening wedge HTO were enrolled. Paired SF samples from the affected knee and arthroscopic evaluation of articular cartilage were collected at the time of HTO surgery and the time of plate removal (postoperative 17±4 months). The concentrations of the following SF biomarkers were measured: interleukin (IL)-1β, IL-6, IL-8, IL-10, tumour necrosis factor-α, matrix metalloproteinase (MMP)-2, MMP-3, MMP-9, MMP-13, vascular endothelial growth factor (VEGF), and cartilage oligomeric matrix protein (COMP). The Knee Society Score (KSS) and hip-knee-ankle (HKA) angle were assessed before and 2 years after HTO. The KSS knee and function scores were significantly improved after HTO (mean changes of 36.4 and 23.7, respectively). The mean HKA angle was altered from mechanical varus (-8.6°) to valgus (5.2°). Concentrations of IL-6, IL-8, MMP-2, MMP-3, MMP-13, VEGF, and COMP in SF were significantly decreased after HTO (mean changes of-49.1%,-30.2%,-31.1%,-26.3%,-30.8%,-42.5%, and-13.7% from preoperative baseline, respectively). The cartilage status was improved in 19 cases (38%) after HTO. However, changes of all biomarkers were not significantly different between subjects with and without an improved cartilage status. SF levels of biochemical markers for cartilage degradation and synovial inflammation were altered after HTO, suggesting an improvement in the OA disease state. |
| Databáze: | OpenAIRE |
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