TL1A as a Potential Local Inducer of IL17A Expression in Colon Mucosa of Inflammatory Bowel Disease Patients

Autor:	Zbigniew Kmieć, Marcin Stanisławowski, Krzysztof Celiński, Marta Cyman, Tomasz Jerzy Ślebioda, Piotr M. Wierzbicki, Jacek Roliński, Agnieszka Bojarska-Junak
Rok vydání:	2015
Předmět:	Adult CD4-Positive T-Lymphocytes Male Tumor Necrosis Factor Ligand Superfamily Member 15 Colon Immunology CD8-Positive T-Lymphocytes Inflammatory bowel disease Pathogenesis Interferon-gamma Crohn Disease Intestinal mucosa medicine Humans RNA Messenger Intestinal Mucosa Colitis Receptors Tumor Necrosis Factor Member 25 Lamina propria Interleukin-13 business.industry Interleukin-17 General Medicine Middle Aged medicine.disease Ulcerative colitis digestive system diseases Up-Regulation Enterocytes medicine.anatomical_structure Colitis Ulcerative Female Tumor necrosis factor alpha Interleukin-4 Interleukin 17 business
Zdroj:	Scandinavian Journal of Immunology. 82:352-360
ISSN:	0300-9475
Popis:	Interaction between TL1A and death receptor 3 (DR3) co-stimulates T cells, induces production of several pro-inflammatory cytokines and has been linked to pathogenesis of inflammatory bowel disease (IBD). This study aimed to establish a link between expression of TL1A and selected TL1A-induced pro-inflammatory cytokines involved in IBD pathogenesis (IL-4, IL-13, IL-17A and IFN-γ) and to investigate a connection between serum concentration of TL1A in patients with IBD and activation of peripheral blood T cells. Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon mucosa of patients with ulcerative colitis (UC), IFN-γ mRNA was upregulated (3.23-fold) in the inflamed colon mucosa of patients with Crohn's disease (CD), whereas upregulation of IL-17A and TL1A mRNA was present in the inflamed colon mucosa of patients with both CD and UC (IL-17A: 4.48-fold and 2.74-fold, TL1A: 3.19-fold and 3.22-fold, respectively) vs. control subjects. We did not detect any changes in DR3 mRNA expression in the investigated groups of patients. TL1A mRNA level in colon mucosa of patients with IBD correlated only with the level of IL-17A mRNA but no other investigated cytokines. In colon mucosa, expression of TL1A and DR3 was localized to enterocytes and lamina propria mononuclear cells. We did not find any correlation between serum concentrations of TL1A and IL-17A or changes of CD4(+) or CD8(+) lymphocytes phenotype in patients with IBD. Therefore, our data indicate that TL1A may contribute to pathogenesis of IBD via local but not systemic induction of IL-17A but not IL-4, IL-13 or IFN-γ.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f90f2e7088a52374811aaa0d4ea3622 https://doi.org/10.1111/sji.12324 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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