No association between vitamin D status and COVID-19 infection in São Paulo, Brazil
| Autor: | Carolina S. Lazari, Maria Izabel Chiamolera, José de Sá, Celso Francisco Hernandes Granato, Pedro de Sá Tavares Russo, Rosa Paula M. Biscolla, José Viana Lima Junior, José Gilberto H. Vieira, Wesley H. Prieto, Cláudia M. Ferrer, Cynthia Brandão |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Coronavirus disease 2019 (COVID-19) Endocrinology Diabetes and Metabolism Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medicine.medical_treatment coronavirus Physiology 030209 endocrinology & metabolism Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Vitamin D and neurology medicine Humans Vitamin D Pandemics business.industry SARS-CoV-2 COVID-19 RC648-665 Vitamin D Deficiency Steroid hormone 030220 oncology & carcinogenesis Medicine Age distribution Female business Specific population Brazil |
| Zdroj: | Archives of Endocrinology and Metabolism, Vol 65, Iss 3, Pp 381-385 (2021) |
| ISSN: | 2359-4292 |
| Popis: | In recent years the immunomodulatory actions of vitamin D, a steroid hormone, have been extensively studied. In 2020, due to the COVID-19 pandemic, the question arose as to 25(OH)D status would be related to susceptibility to SARS-CoV-2 infection, since several studies pointed out a higher prevalence and severity of the disease in populations with low levels of 25(OH)D. Thus, we investigated the 25(OH)D levels in adults “Detected” positive for SARS CoV-2 by RT-PCR (reverse transcriptase polymerase chain reaction) test, and in negative controls, “not Detected”, using the Fleury Group's examination database, in Sao Paulo, Brazil. Of a total of 14.692 people with recent assessments of 25(OH)D and RT-PCR tests for COVID-19, 2.345 were positive and 11.585 were negative for the infection. The groups did not differ in the percentage of men and women, or in the age distribution. There were no differences in the distribution of 25(OH)D between the two groups (p = 0.08); mean 25(OH)D of 28.8 ± 21.4 ng/mL and 29.6 ± 18.1 ng/mL, respectively. In the specific population studied, clinical, environmental, socioeconomic and cultural factors should have greater relevance than 25(OH)D in determining the susceptibility to COVID-19. |
| Databáze: | OpenAIRE |
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