Analysis of determinant factors of liver fibrosis progression in ex-thalassemic patients
| Autor: | Seyed Mostafa Monzavi, Maryam Behfar, Hossein Poustchi, Tahereh Rostami, Alireza Khoshdel, Amir Ali Hamidieh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Adolescent medicine.medical_treatment Thalassemia Graft vs Host Disease Hematopoietic stem cell transplantation Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Transplantation Homologous Prospective Studies Child Bone Marrow Transplantation Univariate analysis Hematology business.industry beta-Thalassemia Hematopoietic Stem Cell Transplantation Beta thalassemia medicine.disease surgical procedures operative Child Preschool 030220 oncology & carcinogenesis Disease Progression Elasticity Imaging Techniques Female Stem cell Hepatic fibrosis business Transient elastography 030215 immunology |
| Zdroj: | International Journal of Hematology. 113:145-157 |
| ISSN: | 1865-3774 0925-5710 |
| DOI: | 10.1007/s12185-020-02998-4 |
| Popis: | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) potentially renders thalassemia patients disease-free with presumably cessation of associated complications. This study analyzes the liver fibrosis status and the determinants of its progression in ex-thalassemic patients. The liver fibrosis status of 108 pediatric transfusion-dependent β-thalassemia major patients was evaluated before and one year after allo-HSCT using transient elastography (TE). All patients achieved normal hematopoiesis. In univariate analyses, not in all, but in patients developing significant post-HSCT iron overload or hepatic graft-versus-host disease (GvHD), as well as recipients of bone marrow stem cells (BMSC), significant TE increment occurred. In multivariable analyses, through a model with large effect size (Adj.R2 = 26%, F(3,104) = 13.53, P |
| Databáze: | OpenAIRE |
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