Growth of kidney-transplanted pediatric patients treated with sirolimus
| Autor: | Clotilde D. García, Natalia Mejía, Gema Ariceta, Fernando Santos, Marta Azocar, Simon Waller, David Anseán González, Angel Alonso |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Graft Rejection
Male Nephrology medicine.medical_specialty Urology Renal function Nephrotoxicity Growth velocity chemistry.chemical_compound Internal medicine Humans Transplantation Homologous Medicine Renal Insufficiency Child Adverse effect Growth Disorders Retrospective Studies Sirolimus Kidney business.industry Kidney Transplantation Surgery Vascular endothelial growth factor medicine.anatomical_structure chemistry Pediatrics Perinatology and Child Health Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | Pediatric Nephrology. 26:961-966 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-011-1811-3 |
| Popis: | Experimental findings indicate that sirolimus (SRL) inhibits longitudinal growth by mechanisms potentially related to its inhibitory effects on both cell proliferation and expression of vascular endothelial growth factor (VEGF). The aim of this study was to investigate the growth pattern of kidney-transplanted children treated with SRL in a multicenter observational clinical study. Height, change in height SD (Δ height) and growth velocity of pediatric patients with renal transplant were calculated at 0, 6, 12, and 24 months after starting SRL. Controls of kidney-transplanted children not treated with SRL were matched by age, gender, renal function, and dose of corticosteroids. Sixty-eight children (34 SRL, 34 controls) were enrolled in the study. Nephrotoxicity was the most frequent indication to start therapy with SRL. SRL exerted an adverse effect on growth as demonstrated by significantly lower (p < 0.05) growth velocity (cm/year) and smaller change in height SD in the SRL group after 6 (4.08 vs. 6.56 and –0.05 vs. 0.14), 12 (4.44 vs. 6.11 and –0.03 vs. 0.28) and 24 (4.53 vs. 6.03 and –0.04 vs. 0.53) months of treatment. This study suggests that SRL therapy may interfere with growth of kidney-transplanted children. This undesirable effect needs to be taken into account when considering a switch to SRL and confirmed in further prospective trials including larger number of patients. |
| Databáze: | OpenAIRE |
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