SATB1 Expression of Colorectal Adenomatous Polyps is Higher than that of Colorectal Carcinomas

Autor:	Mehmet Alparslan Gonultaş, Gülçin Güler Şimşek, Mevlüt Recep Pekcici, Sema Hucumenoglu, Gülsüm Şeyma Yalçin
Rok vydání:	2019
Předmět:	Male 0301 basic medicine medicine.medical_specialty Histology Turkey Colorectal cancer medicine.medical_treatment Kaplan-Meier Estimate medicine.disease_cause Gastroenterology Pathology and Forensic Medicine Targeted therapy Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Mucinous carcinoma neoplasms Aged Mucous Membrane business.industry Matrix Attachment Region Binding Proteins SATB1 Middle Aged Prognosis medicine.disease Immunohistochemistry digestive system diseases Epithelium Medical Laboratory Technology 030104 developmental biology medicine.anatomical_structure Adenomatous Polyposis Coli Dysplasia Lymphatic Metastasis 030220 oncology & carcinogenesis Multivariate Analysis Female Neoplasm Grading Colorectal Neoplasms Carcinogenesis business
Zdroj:	Applied Immunohistochemistry & Molecular Morphology. 28:532-537
ISSN:	1541-2016
DOI:	10.1097/pai.0000000000000791
Popis:	"Special AT-rich sequence-binding protein-1" (SATB1) is a global genome organizer and is found to have effects on carcinogenesis and progression of various malignancies including colorectal carcinoma (CRC). We aimed to investigate the expression of SATB1 in CRC and colorectal adenomatous polyps (CAP), the correlation between clinicopathologic parameters, and overall survival. We examined 227 CRCs and 129 CAPs. SATB1 protein expression was evaluated by immunohistochemistry. We found higher SATB1 expression in adenomatous epithelium than in CRC tissues (55.0% vs. 42.7%, respectively) (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5dfffcd34ef637bd560c133d467ab6 https://doi.org/10.1097/pai.0000000000000791 Zobrazit plný text záznamu