Direct Differentiation of Pathological Changes in the Human Lung Parenchyma With Grating-Based Spectral X-ray Dark-Field Radiography
| Autor: | Korbinian Mechlem, Franz Pfeiffer, Julia Herzen, Fabio De Marco, Daniela Pfeiffer, Kirsten Taphorn, Thorsten Sellerer, Manuel Viermetz |
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| Rok vydání: | 2021 |
| Předmět: |
Lung Diseases
medicine.medical_specialty genetic structures Radiography Grating 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fibrosis Parenchyma Medical imaging Animals Humans Medicine Electrical and Electronic Engineering Lung Radiological and Ultrasound Technology business.industry X-Rays medicine.disease 3. Good health Computer Science Applications Spectral imaging medicine.anatomical_structure Pulmonary Emphysema Differential diagnosis business Software Biomedical engineering |
| Zdroj: | IEEE Transactions on Medical Imaging. 40:1568-1578 |
| ISSN: | 1558-254X 0278-0062 |
| DOI: | 10.1109/tmi.2021.3061253 |
| Popis: | Diagnostic lung imaging is often associated with high radiation dose and lacks sensitivity, especially for diagnosing early stages of structural lung diseases. Therefore, diagnostic imaging methods are required which provide sound diagnosis of lung diseases with a high sensitivity as well as low patient dose. In small animal experiments, the sensitivity of grating-based X-ray dark-field imaging to structural changes in the lung tissue was demonstrated. The energy-dependence of the X-ray dark-field signal of lung tissue is a function of its microstructure and not yet known. Furthermore, conventional X-ray dark-field imaging is not capable of differentiating different types of pathological changes, such as fibrosis and emphysema. Here we demonstrate the potential diagnostic power of grating-based X-ray dark-field in combination with spectral imaging in human chest radiography for the direct differentiation of lung diseases. We investigated the energy-dependent linear diffusion coefficient of simulated lung tissue with different diseases in wave-propagation simulations and validated the results with analytical calculations. Additionally, we modeled spectral X-ray dark-field chest radiography scans to exploit these differences in energy-dependency. The results demonstrate the potential to directly differentiate structural changes in the human lung. Consequently, grating-based spectral X-ray dark-field imaging potentially contributes to the differential diagnosis of structural lung diseases at a clinically relevant dose level. |
| Databáze: | OpenAIRE |
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