Characterization of the nociceptive effect of carrageenan: Masseter versus gastrocnemius
| Autor: | Jesús Esteban-Hernández, Eva M. Sánchez-Robles, Ana Bagüés, M a Isabel Martín‐Fontelles |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Physiology Carrageenan Injections Intramuscular Mechanical Allodynia 03 medical and health sciences Cellular and Molecular Neuroscience Mechanical Hyperalgesia chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Internal medicine Animals Medicine Rats Wistar Muscle Skeletal Acute pain Pain Measurement Masseter Muscle business.industry Chronic pain 030206 dentistry medicine.disease Pathophysiology Rats Treatment Outcome Nociception Endocrinology chemistry Hyperalgesia Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Muscle & Nerve. 56:804-813 |
| ISSN: | 1097-4598 0148-639X |
| Popis: | Introduction To better understand the pathophysiology of chronic muscle pain, there are multiple animal models that mimic different acute/chronic pain conditions, such as carrageenan injection. Our previous studies demonstrated differences between muscles of different innervation in acute pain. In this study we characterized the effect of carrageenan in 2 muscles: masseter (trigeminal innervation) and gastrocnemius (spinal innervation). Methods Carrageenan (3%, 6%, and 9%) was injected into the masseter and gastrocnemius of rats. Mechanical, heat, and chemical nociceptive thresholds were measured for 14 days. Results Carrageenan did not induce mechanical allodynia or thermal hypersensitivity in either muscle. Instead, it induced a short-lasting mechanical hyperalgesia, greater in the masseter than in the gastrocnemius. Conclusion Carrageenan injected into the masseter and gastrocnemius induces a short-lasting hyperalgesia. These results could indicate a higher susceptibility of orofacial muscles to this type of insult and, consequently, a difference between trigeminal and spinal innervation. Muscle Nerve 56: 804-813, 2017. |
| Databáze: | OpenAIRE |
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