MYC mRNA expression throughout the intestine is not associated with body mass index or type 2 diabetes

Autor:	Anne Marie Gade Ellegaard, Filip K Knop
Rok vydání:	2022
Předmět:	Intestines obesity Diabetes Mellitus Type 2 Endocrinology Diabetes and Metabolism mRNA expression Humans type 2 diabetes Glycemic Control RNA Messenger Letter to the Editor Body Mass Index
Zdroj:	Endocrinol Diabetes Metab Ellegaard, A-M & Knop, F K 2022, ' MYC mRNA expression throughout the intestine is not associated with body mass index or type 2 diabetes ', Endocrinology, Diabetes and Metabolism, vol. 5, no. 2, 00327 . https://doi.org/10.1002/edm2.327
ISSN:	2398-9238
Popis:	Inspired by the prospect of intestinal MYC reduction as a putative drug target against metabolic disorders, we investigated MYC mRNA expression in intestinal mucosa biopsies sampled using double‐balloon enteroscopy along the entire intestinal tract of 12 patients with type 2 diabetes and 12 matched healthy controls. In these individuals with body mass index (BMI) ranging from 20 to 31 kg/m(2), the mean MYC mRNA expression varied along the intestine with the lowest level observed at the distal small intestine and the greatest expression levels in the proximal small intestine and in the colon. We do not see a correlation between intestinal mucosal MYC mRNA expression and BMI or glycaemic control, and thus, our findings do not support the hypothesis of intestinal MYC as a putative drug target against obesity and metabolic diseases.[Image: see text]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f432f822da8d0d5f00f6ed6f64b9f46 https://doi.org/10.1002/edm2.327 Zobrazit plný text záznamu Plný text