Putting E. coli on a pedestal: a unique system to study signal transduction and the actin cytoskeleton

Autor:	Myriam de Grado, Danika L. Goosney, B. Brett Finlay
Rok vydání:	1999
Předmět:	Diarrhea Virulence biology Actin remodeling Arp2/3 complex macromolecular substances Cell Biology Actin cytoskeleton Actins Bacterial Adhesion Cell biology Profilin Escherichia coli biology.protein Animals Enteropathogenic Escherichia coli Signal transduction Cytoskeleton Actin Signal Transduction
Zdroj:	Trends in Cell Biology. 9:11-14
ISSN:	0962-8924
DOI:	10.1016/s0962-8924(98)01418-4
Popis:	Enteropathogenic Escherichia coli (EPEC) subverts host signalling pathways and the cytoskeleton during infection, resulting in disease characterized by diarrhoea. Recent studies have revolutionized our understanding of the infection process by showing that this bacterium inserts its own receptor into the plasma membrane overlying the host actin cytoskeleton. The reorganized actin forms a pedestal-like structure with the bacterium at the tip. This review discusses the mechanism of infection and pedestal formation and how this system might be a powerful tool for studying actin dynamics at the plasma membrane.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3d7b1bbb20fb0391055d6ff34a1a57 https://doi.org/10.1016/s0962-8924(98)01418-4 Zobrazit plný text záznamu Full Text from ScienceDirect