Prenatal markers and longitudinal follow-up in simple and complex gastroschisis
| Autor: | Dick Tibboel, Annelieke Hijkoop, Titia E. Cohen-Overbeek, Rene M. H. Wijnen, Hanneke IJsselstijn, Joost van Rosmalen |
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| Přispěvatelé: | Pediatric Surgery, Epidemiology, Obstetrics & Gynecology |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Population Gestational Age Logistic regression Bayley Scales of Infant Development Ultrasonography Prenatal Fetal Development 03 medical and health sciences Child Development 0302 clinical medicine Pregnancy 030225 pediatrics Humans Medicine education Retrospective Studies Gastroschisis Psychomotor learning education.field_of_study Fetal Growth Retardation 030219 obstetrics & reproductive medicine business.industry Abdominal wall defect Infant Obstetrics and Gynecology General Medicine medicine.disease Increased risk Neurodevelopmental Disorders Child Preschool Pediatrics Perinatology and Child Health Gestation Female Psychomotor Disorders business Follow-Up Studies |
| Zdroj: | Archives of Disease in Childhood. Fetal and Neonatal Edition, 103(2), F126-F131. BMJ Publishing Group |
| ISSN: | 1468-2052 1359-2998 |
| DOI: | 10.1136/archdischild-2016-312417 |
| Popis: | ObjectiveWe aimed to identify gestational-age corrected prenatal ultrasound markers of complex gastroschisis, and to compare physical growth and neurodevelopment between children with simple and complex gastroschisis.DesignWe included prenatally diagnosed gastroschisis patients from 2000 to 2012 who joined our longitudinal follow-up programme. Associations between complex gastroschisis and prenatal ultrasound markers collected at 30 weeks’ gestation and prior to delivery were tested using logistic regression. Physical growth (SD scores (SDS)), mental and psychomotor developmental index (MDI, PDI; Bayley Scales of Infant Development) were recorded at 12 and 24 months. Data were analysed using general linear models and compared with population norms.ResultsData of 61 children were analysed (82% of eligible cases). Extra-abdominal bowel dilatation at 30 weeks’ gestation was significantly associated with complex gastroschisis (OR (95% CI): 5.00 (1.09 to 22.98)), with a high negative (88%) but low positive (40%) predictive value. The mean (95% CI) height SDS at 12 months (−0.46 (–0.82 to –0.11)), and weight SDS at 12 and 24 months (−0.45 (–0.85 to –0.05), and −0.44 (−0.87 to –0.01), respectively) fell significantly below 0 SDS. MDI and PDI were significantly below 100 at 24 months; 93 (88 to 99) and 83 (78 to 87), respectively). Children with complex gastroschisis had a significantly lower PDI (76 (68 to 84)) than those with simple gastroschisis (94 (90 to 97), pConclusionsPrenatal ultrasound markers could not reliably distinguish between simple and complex gastroschisis. Children with complex gastroschisis may be at increased risk for delayed psychomotor development; they should be monitored more closely, and offered timely intervention. |
| Databáze: | OpenAIRE |
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