Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons
| Autor: | Robert W. Mahley, Jens Brodbeck, Ann M. Saunders, Yadong Huang, Maureen E. Balestra, Allen D. Roses |
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| Rok vydání: | 2008 |
| Předmět: |
Agonist
medicine.medical_specialty Dendritic spine Apolipoprotein B medicine.drug_class Dendritic Spines medicine.medical_treatment Apolipoprotein E4 Synaptogenesis Cell Count Rosiglitazone Insulin resistance Internal medicine medicine Animals Receptor Cells Cultured Cerebral Cortex Neurons Multidisciplinary biology Insulin Dendrites Biological Sciences medicine.disease Rats Endocrinology Animals Newborn biology.protein Thiazolidinediones medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences. 105:1343-1346 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0709906104 |
| Popis: | Convergent evidence has revealed an association between insulin resistance and Alzheimer's disease (AD), and the peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, rosiglitazone, an insulin sensitizer and mitochondrial activator, improves cognition in patients with early or mild-to-moderate AD. Apolipoprotein (apo) E4, a major genetic risk factor for AD, exerts neuropathological effects through multiple pathways, including impairment of dendritic spine structure and mitochondrial function. Here we show that rosiglitazone significantly increased dendritic spine density in a dose-dependent manner in cultured primary cortical rat neurons. This effect was abolished by the PPAR-γ-specific antagonist, GW9662, suggesting that rosiglitazone exerts this effect by activating the PPAR-γ pathway. Furthermore, the C-terminal-truncated fragment of apoE4 significantly decreased dendritic spine density. Rosiglitazone rescued this detrimental effect. Thus, rosiglitazone might improve cognition in AD patients by increasing dendritic spine density. |
| Databáze: | OpenAIRE |
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