The relationship between IL-17A and IL-22 expression and clinical severity in patients with moderate/severe persistent allergic rhinitis
| Autor: | Loghman Salimzadeh, Soroush Amani, Ghadir Tavakoli, Hedayatollah Shirzad, Omid Zargari Samani, Mostafa Gholami Arjenaki, Fatemeh Deris, Mohamad Ali Zamani, Mandana Moghni, Seyyedeh Maryam Kazemi, Ashkan Pirayesh, Shaghayegh Shahsavan, Nader Bageri |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Mucous membrane of nose Gastroenterology Severity of Illness Index Interleukin 22 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Severity of illness medicine Humans In patient Clinical severity Young adult 030223 otorhinolaryngology business.industry Interleukins Interleukin-17 Eosinophil Rhinitis Allergic medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Immunohistochemistry Female Inflammation Mediators business Biomarkers |
| Zdroj: | American journal of otolaryngology. 40(2) |
| ISSN: | 1532-818X |
| Popis: | Purpose Several reactions leading to numerous effects are regulated by IL-22. However, the relationship between IL-22 and immunopathogensis of allergic rhinitis (AR) has been rarely investigated. The aim of the present study was to investigate the levels of IL-22 and IL-17A in AR patients and their association with clinical severity of persistent allergic rhinitis (PAR). Materials and methods Thirty mild persistent allergic rhinitis (M PAR) patients, thirty moderate/severe persistent allergic rhinitis (M/S PAR) patients, and thirty healthy controls were enrolled in this study. Local production of IL-22 and IL-17A in PAR patients and healthy controls' nasal mucosa was examined by immunohistochemistry (IHC) and real-time polymerase chain reaction (RT-PCR) techniques. Serum levels of IL-22, IL-17A, specific immunoglobulin E (sIgE), and total IgE (tIgE) in PAR patients and healthy controls were determined by ELISA. In addition, blood eosinophil, nasal eosinophils per field, and total nasal syndrome score (TNSS) were also assessed. Results In comparison with healthy controls, production of IL-22 and IL-17A in M/S PAR patients increased significantly. Furthermore, serum levels as well as the mean number of IL-22+ and IL-17A+ cells in nasal mucosa correlated with sIgE, nasal eosinophil count, and TNSS. Conclusion The results of the present study provide the first evidence that local production of IL-22 might be expressed in PAR patients. The expression of IL-22 and IL-17A, and their correlations with clinical parameters in PAR patients suggest the role of these cytokines in the events involved in the development of PAR. |
| Databáze: | OpenAIRE |
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