Rituximab therapy for IgA-vasculitis with nephritis: a case series and review of the literature
| Autor: | Giulietta Beltrame, Giacomo Quattrocchio, Bruno Basolo, Paola Mesiano, Dario Roccatello, Michela Ferro, Roberta Fenoglio, Carla Naretto |
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| Rok vydání: | 2016 |
| Předmět: |
Immunoglobulin A
Adult Male Allergy Cyclophosphamide IgA Vasculitis Immunology 030232 urology & nephrology Azathioprine 03 medical and health sciences Young Adult 0302 clinical medicine medicine Humans Aged 030203 arthritis & rheumatology Henoch–Schonlein treatment Nephritis biology IgA-vasculitis business.industry Middle Aged medicine.disease IgA vasculitis B cell depletion therapy biology.protein Henoch–Schonlein purpura nephritis Rituximab Female Vasculitis business ANCA-associated vasculitis Immunosuppressive Agents medicine.drug |
| Zdroj: | Immunologic research. 65(1) |
| ISSN: | 1559-0755 |
| Popis: | Henoch-Schonlein purpura, also called IgA-vasculitis, is a systemic small vessels vasculitis with immunoglobulin A1-dominant immune deposits. The optimal treatment remains controversial. Because IgA-vasculitis is characterized by leukocyte infiltration of the blood vessel walls along with immunoglobulin A deposition, and because glucocorticosteroids inhibit inflammatory processes, early administration of glucocorticosteroids has been postulated to be effective, but this indication remains controversial. Immunosuppressive agents (azathioprine, cyclophosphamide, cyclosporine, mycophenolate) have been used in combination with glucocorticosteroids without definitive evidence of effectiveness. The efficacy of rituximab in adult IgA-vasculitis has been reported in few cases. We described a monocentric experience on the use of rituximab in adult IgA-vasculitis with biopsy-proven nephritis. The patients achieved a complete remission of nephritis and syndromic manifestations, and no patients experienced adverse reactions. These data have been compared with the limited literature nowadays available. |
| Databáze: | OpenAIRE |
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