Cutaneous Disorders Associated with Castleman's Disease
| Autor: | Jun Young Lee, Chul Hwan Bang, Ji Hyun Lee, Kyung Shin Park, Hyo Jung Kim, Hyun Jung Park, Kyung Moon Kim, Ju Hee Han, Dong Su Yoo, Young Min Park, Seok-Goo Cho |
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| Rok vydání: | 2019 |
| Předmět: |
Male
viruses Castleman’s disease Skin Pigmentation Disease Antigen-Antibody Complex paraneoplastic itch Angioma 030207 dermatology & venereal diseases 0302 clinical medicine immune system diseases Risk Factors hemic and lymphatic diseases lcsh:Dermatology Child Skin biology virus diseases General Medicine Middle Aged POEMS syndrome 030220 oncology & carcinogenesis Child Preschool Cytokines Female medicine.symptom lymphoproliferative disorder Adult medicine.medical_specialty Adolescent Seoul Dermatology Skin Diseases Lesion 03 medical and health sciences Young Adult medicine Humans Interleukin 6 Retrospective Studies business.industry interleukin-6 Castleman Disease lcsh:RL1-803 medicine.disease Hyperpigmentation Paraneoplastic pemphigus biology.protein business Rare disease |
| Zdroj: | Acta Dermato-Venereologica, Vol 99, Iss 11, Pp 984-989 (2019) |
| ISSN: | 1651-2057 |
| Popis: | Castleman's disease is a rare disease of the lymph nodes and related tissues, presenting as angiofollicular or giant lymph node hyperplasia. Although various skin manifestations have been reported to occur in Castleman's disease, a comprehensive study of cutaneous disorders in Castleman's disease is lacking. Therefore, the aim of this study was to investigate Castleman's disease-associated cutaneous disorders. The medical records of 57 patients with Castleman's disease who visited our hospitals from January 2007 to May 2018 were analysed retrospectively. Patients were classified according to the presence of skin involvement. Plasma variant-type Castleman's disease and multicentric Castleman's disease were more commonly found in patients with Castleman's disease with a cutaneous disorder than in those without a cutaneous disorder. In addition, the skin disorders were classified according to pathomechanisms: immune complex-related (paraneoplastic pemphigus, xanthogranulomas), cytokine-related (vasculitis-like lesion, cherry angioma, hyperpigmentation), and non-specific (pruritus). This study builds on previous case reports of cutaneous disorders in Castleman's disease and proposes a new classification system. |
| Databáze: | OpenAIRE |
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