Protean Neurologic Manifestations of Two Rare Dermatologic Disorders: Sweet Disease and Localized Craniofacial Scleroderma
| Autor: | Andrew G. Franks, Asya I. Wallach, Ilya Kister, Cynthia M. Magro, Lee Shapiro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neurology Disease Skin Diseases Scleroderma 03 medical and health sciences Scleroderma Localized 0302 clinical medicine Seizures medicine Humans Cognitive decline Localized Scleroderma Skin integumentary system business.industry General Neuroscience Sweet Syndrome Headache medicine.disease Dermatology 030104 developmental biology Disease Progression Neurology (clinical) Headaches medicine.symptom business 030217 neurology & neurosurgery Morphea |
| Zdroj: | Current neurology and neuroscience reports. 19(3) |
| ISSN: | 1534-6293 |
| Popis: | To describe diverse neurologic and neuroradiologic presentations of two rare, immunologically mediated skin conditions: Sweet disease and localized scleroderma (morphea). Core syndromes of neuro-Sweet disease (NSD) are steroid responsiveness, recurrent meningitis, and encephalitis. Focal neurologic, neuro-vascular, and neuro-ophthalmologic syndromes have been reported recently in NSD. A variety of steroid-sparing treatments and biologics have been used for relapsing NSD. Localized craniofacial scleroderma is associated with seizures, headaches, and less commonly, focal deficits and cognitive decline. Immunosuppressive therapy may be required in patients with disease progression; some refractory cases have responded to IL-6 inhibition. Our review provides an up-to-date reference for neurologists faced with a patient with a history or skin findings consistent with Sweet disease or localized scleroderma. We hope that it will stimulate collaborative studies aimed at unraveling the pathogenesis of these disorders, better characterization of their neurologic manifestations, and discovery of optimal therapeutic solutions. |
| Databáze: | OpenAIRE |
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