Discovery of Brainwide Neural-Behavioral Maps via Multiscale Unsupervised Structure Learning
| Autor: | Marta Zlatic, Joshua T. Vogelstein, Carey E. Priebe, Youngser Park, James W. Truman, Tomoko Ohyama, Rex Kerr |
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| Rok vydání: | 2014 |
| Předmět: |
Motor Neurons
Neurons Nervous system Brain Mapping Behavioral phenotypes Multidisciplinary Behavior Animal Atlas (topology) Computer science Movement Brain Optogenetics Drosophila melanogaster medicine.anatomical_structure Behavioral data Artificial Intelligence Larva medicine Animals Neuron Structure learning Neuroscience Locomotion Drosophila larvae |
| Zdroj: | Science. 344:386-392 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Optogenetic Insights Mapping functional neural circuits for many behaviors has been almost impossible, so Vogelstein et al. (p. 386 , published online 27 March; see the Perspective by O'Leary and Marder ) developed a broadly applicable optogenetic method for neuron-behavior mapping and used it to phenotype larval Drosophila and thus developed a reference atlas. As optogenetic experiments become routine in certain fields of neuroscience research, creating even more specialized tools is imperative (see the Perspective by Hayashi ). By engineering channelrhodopsin, Wietek et al. (p. 409 , published online 27 March) and Berndt et al. (p. 420 ) created two different light-gated anion channels to block action potential generation during synaptic stimulation or depolarizing current injections. These new tools not only improve understanding of channelrhodopsins but also provide a way to silence cells. |
| Databáze: | OpenAIRE |
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