Kinetically Controllable Pd-Catalyzed Decarboxylation Enabled [5 + 2] and [3 + 2] Cycloaddition toward Carbocycles Featuring Quaternary Carbons
| Autor: | Yang Liu, Biwei Yan, Xiaowei Chang, Teng Liu, Haiyu Sun, Wusheng Guo, Linhong Zuo, Weipeng Chen, Manying Cui |
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| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Decarboxylation Chemistry Organic Chemistry Kinetics chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Cycloaddition 0104 chemical sciences Catalysis chemistry.chemical_compound Zwitterion Physical and Theoretical Chemistry Palladium |
| Zdroj: | Organic Letters. 23:351-357 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A decarboxylative protocol has been developed toward a range of carbocycles. The key success is based on the use of a batch of newly designed cyclic carbonates as substrates that can provide carbon-carbon zwitterion intermediate under palladium catalysis. The kinetics of the reactions are controllable toward either strained seven- or thermodynamically more favored five-membered carbocycles. The release of this chemistry will shed light on the synthesis of complex and valuable cyclic structures. |
| Databáze: | OpenAIRE |
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