Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by Osa
| Autor: | Luc Vanolst, Philippe Ramain, Pascal Heitzler, Inna Biryukova |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Cell Cycle Proteins
Biology Nervous System Chromatin remodeling Research Communication Bacterial Proteins Enhancer binding Gene expression Genetics Animals Drosophila Proteins Enhancer Promoter Regions Genetic Psychological repression Helix-Loop-Helix Motifs Nuclear Proteins Chromatin Cell biology Enhancer Elements Genetic Gene Expression Regulation Trans-Activators Drosophila Scute Developmental Biology Transcription Factors |
| Zdroj: | Genesdevelopment. 17(5) |
| ISSN: | 0890-9369 |
| Popis: | The GATA factor Pannier activates proneuralachaete/scute(ac/sc) expression during development of the sensory organs ofDrosophilathrough enhancer binding. Chip bridges Pannier with the (Ac/Sc)–Daughterless heterodimers bound to the promoter and facilitates the enhancer–promoter communication required for proneural development. We show here that this communication is regulated by Osa, which is recruited by Pannier and Chip. Osa belongs to Brahma chromatin remodeling complexes and we show that Osa negatively regulatesac/sc. Consequently, Pannier and Chip also play an essential role during repression of proneural gene expression. Our study suggests that altering chromatin structure is essential for regulation of enhancer–promoter communication. |
| Databáze: | OpenAIRE |
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