Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva
| Autor: | Blanca Patricia Lazalde-Ramos, López-Verdín S, Rogelio González-González, Ronell Bologna-Molina, Soto-Avila Jj, Ana Lourdes Zamora-Perez, Margarita L Martinez-Fierro, Mario A. Isiordia-Espinoza, Nelly Molina-Frechero |
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| Přispěvatelé: | Lopez-Verdín S, Universidad de Guadalajara (México), Soto-Avila JJ, Instituto Jalisciense de Cancerología (México), Zamora-Pérez AL, Universidad de Guadalajara (México), Lazalde-Ramos BP, Universidad Autónoma de Zacatecas (México), Martínez-Fierro M de la Luz, Universidad Autónoma de Zacatecas (México), González-González R., Universidad Juárez del Estado de Durango (México), Molina-Frechero N., Universidad Autónoma Metropolitana (Mexico), Isiordia-Espinoza MA, Universidad Autónoma de San Luis Potosí (México), Bologna-Molina Ronell, Universidad de la República (Uruguay). Facultad de Odontología |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Saliva E-cadher.in Disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Carcinoma Humans Stage (cooking) General Dentistry Lymph node Neoplasm Staging Oral Medicine and Pathology Cadherin business.industry Research Oral cancer Cancer Middle Aged medicine.disease CIENCIAS MÉDICAS [UNESCO] Cadherins 030104 developmental biology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis UNESCO::CIENCIAS MÉDICAS Carcinoma Squamous Cell Immunohistochemistry Surgery Female Mouth Neoplasms business |
| Zdroj: | COLIBRI Universidad de la República instacron:Universidad de la República Medicina Oral, Patología Oral y Cirugía Bucal López-Verdín, Sandra ; Soto-Avila, Juan-José ; Zamora Pérez, Ana Lourdes ; Lazalde Ramos, Blanca Patricia ; Martínez-Fierro, Margarita de la Luz ; González González, Rogelio ; Molina Frechero, Nelly ; Espinoza, Mario Alberto Isiordia ; Bologna Molina, Ronell. Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 6 2017: 5 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname |
| Popis: | Background: The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the resence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Material and Methods: Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immunohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method. Patients without cancer were included in the study as a control group for comparisons of the sE-cadherin levels. Results: sE-cadherin levels in the saliva of patients without cancer were lower than those in patients with cancer, and the difference was statistically significant (p=0.031). Low mE-cadherin xpression was statistically significantly associated with lymph node positivity (p=0.015) and advanced clinical stage (p=0.001). The inverse relationship between mE-cadherin and sE-cadherin was significant in terms of lymph node positivity (p=0.014) and advanced clinical stage (p=0.037). Background: The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the resence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Material and Methods: Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immunohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method. Patients without cancer were included in the study as a control group for comparisons of the sE-cadherin levels. Results: sE-cadherin levels in the saliva of patients without cancer were lower than those in patients with cancer, and the difference was statistically significant (p=0.031). Low mE-cadherin xpression was statistically significantly associated with lymph node positivity (p=0.015) and advanced clinical stage (p=0.001). The inverse relationship between mE-cadherin and sE-cadherin was significant in terms of lymph node positivity (p=0.014) and advanced clinical stage (p=0.037). Background: The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the resence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Material and Methods: Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immunohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method. Patients without cancer were included in the study as a control group for comparisons of the sE-cadherin levels. Results: sE-cadherin levels in the saliva of patients without cancer were lower than those in patients with cancer, and the difference was statistically significant (p=0.031). Low mE-cadherin xpression was statistically significantly associated with lymph node positivity (p=0.015) and advanced clinical stage (p=0.001). The inverse relationship between mE-cadherin and sE-cadherin was significant in terms of lymph node positivity (p=0.014) and advanced clinical stage (p=0.037). |
| Databáze: | OpenAIRE |
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