Can a Nine-month Regimen be Used to Treat Isoniazid Resistant Tuberculosis Diagnosed after Standard Treatment is Started?
| Autor: | N. Horsfield, R.M. Green, L.P. Ormerod |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Time Factors Tuberculosis Antitubercular Agents Drug Administration Schedule Internal medicine Tuberculosis Multidrug-Resistant Isoniazid medicine Humans Ethambutol Aged Retrospective Studies Antibacterial agent business.industry Standard treatment Drug Resistance Microbial Middle Aged Pyrazinamide medicine.disease Surgery Clinical trial Regimen Treatment Outcome Infectious Diseases Female business Rifampicin medicine.drug |
| Zdroj: | Journal of Infection. 42:1-3 |
| ISSN: | 0163-4453 |
| DOI: | 10.1053/jinf.2000.0773 |
| Popis: | Objectives : National tuberculosis treatment guidelines suggest a regimen of 2RZE/10RE for the treatment of isoniazid resistant organisms. A retrospective clinical study of all patients treated for non-MDR-TB isoniazid-resistant organisms was undertaken. Methods : A continuous database of the patients treated between 1978–1999 inclusive was examined to determine the regimens used and the outcome of treatment for such patients. Results : Thirty-seven patients were identified. Eighteen had regimens of greater than 9 months, 19 had regimens of 9 months or less. No relapses occurred in those cases treated with a regimen of 2RZE/7RE during 12 months' minimum follow-up. Conclusions : A regimen of 2RZE/7RE may be possible for the treatment of isoniazid-resistant organisms if given either under close supervision or as a formally supervised regimen. Larger clinical studies or a controlled clinical trial are needed to confirm these initial findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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