Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia
| Autor: | Małgorzata Polubiec-Kownacka, Adriana Rozy, Elżbieta Radzikowska, Elżbieta Wiatr, Joanna Chorostowska-Wynimko, Paulina Jagus, Kazimierz Roszkowski-Śliż |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Gastroenterology General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Clarithromycin Internal medicine Internal Medicine medicine Humans Pharmacology (medical) Interleukin 8 Interleukin 6 Genetics (clinical) Aged biology medicine.diagnostic_test Interleukin-6 business.industry Middle Aged Respiratory Function Tests Interleukin 1β Cytokine Bronchoalveolar lavage 030228 respiratory system Cryptogenic Organizing Pneumonia Reviews and References (medical) Immunology biology.protein Female business Bronchoalveolar Lavage Fluid 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Advances in Clinical and Experimental Medicine. 25:871-878 |
| ISSN: | 1899-5276 |
| DOI: | 10.17219/acem/61953 |
| Popis: | Background Inflammatory cytokines are involved in the development of cryptogenic organizing pneumonia (COP). It has been shown that macrolides inhibit cytokine production in the alveolar macrophages of COP patients. Objectives The aim of the study was to assess the concentrations of interleukin 1β (IL-1β), IL-6, IL-8 and transforming growth factor β (TGF-β) in serum and in bronchoalveolar lavage fluid (BAL-f) in COP patients treated with clarithromycin (CAM). Material and methods The study involved 26 patients (18 women and 8 men, mean age 56.46 ± 8.83 years) with biopsy-proven COP. After being treated with CAM, a complete recovery was achieved in 22 patients, while four patients did not respond to the treatment. The ELISA method was used to measure the serum and BAL-f concentrations of IL-1β, IL-6, IL-8 and TGF-β. Results Before treatment, the serum IL-1β1, IL-6, IL-8 and TGF-β1 concentrations were similar in responders and non-responders. Significant decreases in serum concentrations of IL-6 (8.98 ± 13.26 pg/mL vs. 3.1 ± 6.95 pg/mL; p = 0.005), IL-8 (20.14 ± 25.72 pg/mL vs. 10.14 ± 6.8 pg/mL; p = 0.007) and TGF-β1 (37.89 ± 12.49 ng/mL vs. 26.49 ± 12.45 ng/mL; p = 0.001) were found after treatment, as well as a significant decrease in the BAL-f concentration of IL-6 (30.56 ± 56.78 pg/mL vs. 4.53 ± 5.84 pg/mL; p = 0.036). Clarithromycin treatment resulted in a significantly lower mean value of serum IL-6 responders than non-responders. Conclusions In COP patients, response to clarithromycin treatment was associated with decreases in serum concentrations of IL-6, IL-8 and TGF-β, and of rations, and of the BAL-f concentration of IL-6. |
| Databáze: | OpenAIRE |
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