Clinical surveillance of thrombotic microangiopathies in Scotland, 2003–2005
| Autor: | W. T. A. Todd, David Young, T. J. Beattie, Kevin G.J. Pollock |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Serotype medicine.medical_specialty Adolescent Databases Factual Epidemiology medicine.medical_treatment Thrombotic thrombocytopenic purpura Escherichia coli O157 Shiga Toxins Sex Factors Surveys and Questionnaires hemic and lymphatic diseases Internal medicine Escherichia coli medicine Coagulopathy Humans Prospective Studies QA Prospective cohort study business.industry Age Factors Immunosuppression Length of Stay Middle Aged medicine.disease Original Papers QR Infectious Diseases Purpura Thrombocytopenic Scotland Population Surveillance Hemolytic-Uremic Syndrome Immunology Etiology Female business Kidney disease |
| Zdroj: | Epidemiology and Infection. 136:115-121 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268807008217 |
| Popis: | SUMMARYThe prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management strategies using prospective, national surveillance of HUS and TTP, from 2003 to 2005 inclusive. We also investigated the links between these disorders and factors implicated in the aetiology of HUS and TTP including infections, chemotherapy, and immunosuppression. Most cases of HUS were caused by verocytotoxin-producingEscherichia coli(VTEC), of which serotype O157 predominated, although other serotypes were identified. The list of predisposing factors for TTP was more varied although use of immunosuppressive agents and severe sepsis, were the most frequent precipitants. The study demonstrates that while differentiating between HUS and TTP is sometimes difficult, in most cases the two syndromes have quite different predisposing factors and clinical parameters, enabling clinical and epidemiological profiling for these disorders. |
| Databáze: | OpenAIRE |
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