Validation of the Pancreatic Donor Risk Index in Simultaneous Pancreas-Kidney Transplantation Performed in Córdoba Hospital From 2000 to 2015
| Autor: | J.P. Campos-Hernández, J. Carrasco-Valiente, J. Ruiz-García, Juan Ruiz-Rabelo, J.J. Salamanca-Bustos, Álvaro Arjona-Sánchez, J.M. Sánchez-Hidalgo, A. Sanchez-gonzalez, J. Briceño-Delgado, A.J. Arenas-Bonilla, M.J. Requena-Tapia, J.C. Regueiro-López |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Urology 030209 endocrinology & metabolism Kaplan-Meier Estimate Pancreas transplantation Risk Assessment Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Humans Medicine 030212 general & internal medicine Survival analysis Retrospective Studies Cause of death Transplantation Surgical team business.industry Proportional hazards model Graft Survival Kidney Transplantation Hospitals Tissue Donors United States Surgery surgical procedures operative medicine.anatomical_structure Regression Analysis Female Pancreas Transplantation business Pancreas Body mass index |
| Zdroj: | Transplantation Proceedings. 48:3037-3039 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2016.07.049 |
| Popis: | Background The Pancreatic Donor Risk Index (PDRI) was developed in 2010 in the United States to predict graft survival after pancreas transplantation, based on donor characteristics and logistical and technical conditions. The aim of the study was to validate the utility of PDRI as a pancreas allograft survival predictor in simultaneous pancreas-kidney transplantation (SPK) transplants performed in our hospital between 2000 and 2015. Methods This retrospective analysis of 126 SPK transplants was performed by the same surgical team from the years 2000 to 2015. Donor variables that are integrated in the PDRI were calculated (age, sex, race, creatinine serum levels, body mass index, height, cold ischemia time, cause of death, type of pancreas transplant). Pancreatic graft survival at 1 and 5 years was calculated by use of the Kaplan-Meier test. Comparison of survival curves between PDRI risk quartiles was calculated by use of the log-rank test. Association between graft survival and variables integrating the PDRI was calculated by use of univariate Cox regression analysis. Results Log-rank analysis found no statistically significant association between global graft survival and PDRI quartiles. Univariate Cox regression analysis showed a statistically significant association between graft survival and cold ischemia time ( P Conclusions PDRI was not a useful tool to predict pancreatic graft outcomes in a Spanish reference population. |
| Databáze: | OpenAIRE |
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