Can p53 nuclear over-expression, Bcl-2 accumulation and PCNA status be of prognostic significance in high-risk superficial and invasive bladder tumours?
| Autor: | M. Petrakos, D. Plastiras, Ch. Theodorou, C. Barbatis, V. Presvelos, G. Moutzouris |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Risk Oncology medicine.medical_specialty Pathology Disease Antigens Neoplasm Predictive Value of Tests Proliferating Cell Nuclear Antigen Internal medicine Biomarkers Tumor medicine Humans Neoplasm Invasiveness Aged Aged 80 and over Urinary bladder Bladder cancer biology business.industry Cancer General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Up-Regulation Proliferating cell nuclear antigen Gene Expression Regulation Neoplastic medicine.anatomical_structure Transitional cell carcinoma Proto-Oncogene Proteins c-bcl-2 Urinary Bladder Neoplasms Cohort biology.protein Surgery Tumor Suppressor Protein p53 business |
| Zdroj: | European Journal of Surgical Oncology (EJSO). 25:61-65 |
| ISSN: | 0748-7983 |
| Popis: | Aims To evaluate p53 and Bcl-2 expression and proliferating status (PCNA) in subgroups of patients with high-risk superficial and invasive bladder cancer, with relation to cancer progression and death, and to correlate the results with established clinical prognostic factors. Methods Paraffin-embedded sections from 42 high-risk superficial (T 1 G 2 ,T 1 G 3 ) and 33 invasive (T 2 –T 4a G 3 N 0 M 0 ) tumours were investigated immunohistochemically for p53, Bcl-2 and PCNA. The median follow-up was 52 months. Results In the cohort of superficial tumours, statistical analysis showed that p53 and PCNA positivity were significant prognostic factors ( P -values: 0.008 and 0.006, respectively) for disease-specific death (DSD). When life expectancy was evaluated (log-rank test), p53(+) ( P =0.015) and PCNA(+) ( P =0.017) offered the most accurate prognosis compared to grade, tumour size and multiplicity. Bcl-2 status had no significant effect on patient survival. In the subset of muscle-invasive tumours we failed to demonstrate any important role of p53, Bcl-2 or PCNA positivity. Conclusions p53 and PCNA over-expression may offer valuable additional prognostic information in high-risk subgroups of superficial bladder tumours. From our results, Bcl-2 does not appear to contribute significantly to the prognosis of these patients. None of the studied markers offered prognostic information in muscle-invading disease. |
| Databáze: | OpenAIRE |
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